1. Figure 5 PPIs and adverse events with proven and unproven causality
Figure 5 | PPIs and adverse events with proven and unproven causality. The number of complications associated with proton-pump inhibitors (PPIs) is high. This figure shows the adverse events linked to PPI use, with indicators of the evidence supporting causality. Those events with proposed major importance in clinical practice are shown according to the scientific evidence and grading as per Table 1. *Enteric infections with Salmonella enterica subsp. enterica serovar Enteritidis, Salmonella enterica subsp. enterica serovarTyphimurium and Campylobacter jejuni. ‡Association restricted to omeprazole; the FDA recommends avoiding the concomitant use of clopidogrel and omeprazole127. SIBO, small intestinal bacterial overgrowth.
Malfertheiner, P. et al. (2017) Proton-pump inhibitors: understanding the complications and risks
Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro