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Activity-Based Profiling for Drug Discovery

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Presentation on theme: "Activity-Based Profiling for Drug Discovery"— Presentation transcript:

1 Activity-Based Profiling for Drug Discovery
Remigiusz Serwa, Edward W. Tate  Chemistry & Biology  Volume 18, Issue 4, Pages (April 2011) DOI: /j.chembiol Copyright © 2011 Elsevier Ltd Terms and Conditions

2 Figure 1 Discovery of JW480: Activity-Based Protein Profiling in Action ABPP-assisted discovery of selective inhibitor JW480 against serine protease KIAA1363, the activity of which is upregulated in aggressive cancer cells. Orally administered JW480 also significantly impaired the growth of tumor in a mouse xenograph model. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2011 Elsevier Ltd Terms and Conditions

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