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Folding research recruits unconventional help

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Presentation on theme: "Folding research recruits unconventional help"— Presentation transcript:

1 Folding research recruits unconventional help
Michael Gross  Current Biology  Volume 22, Issue 2, Pages R35-R38 (January 2012) DOI: /j.cub Copyright © Terms and Conditions

2 Folding puzzle: The rearrangement of a linear polymer into a compact three-dimensional shape proceeds autonomously in nature but is still puzzling biochemists. (Photo: Michael Gross.) Current Biology  , R35-R38DOI: ( /j.cub ) Copyright © Terms and Conditions

3 Folding fun: Tens of thousands of online game players around the world have contributed to folding research via the game Foldit, developed at the University of Washington at Seattle. (Photo: Mohini Patel Glanz.) Current Biology  , R35-R38DOI: ( /j.cub ) Copyright © Terms and Conditions

4 Folding target: The target structure of the CASP8 competition (coloured) compared with the predictions submitted (grey). (Photo: Daniel Keedy, Jane S. Richardson — Source Wikimedia commons.) Current Biology  , R35-R38DOI: ( /j.cub ) Copyright © Terms and Conditions

5 Prediction progress: Predicted (left) and experimental (right) structure of the Ras G domain studied by Debora Marks et al. using only evolutionary constraints for the prediction. (Image reproduced with permission from Marks D.S. et al. (2011). Protein 3D structure computed from evolutionary sequence variation. PLoS One 6, e doi: /journal.pone ) Current Biology  , R35-R38DOI: ( /j.cub ) Copyright © Terms and Conditions


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