1. Dexmedetomidine pharmacodynamics in healthy volunteers: 2
Dexmedetomidine pharmacodynamics in healthy volunteers: 2. Haemodynamic profile 
P.J. Colin, L.N. Hannivoort, D.J. Eleveld, K.M.E.M. Reyntjens, A.R. Absalom, H.E.M. Vereecke, M.M.R.F. Struys 
British Journal of Anaesthesia 
Volume 119, Issue 2, Pages (August 2017)
DOI: /bja/aex086
Copyright © 2017 The Author(s) Terms and Conditions

2. Fig 1
Mean arterial pressure (continuous pink lines; grey y-axis labels) and heart rate (solid blue lines; black y-axis labels) for four representative subjects. The nominal times (as indicated by the study protocol) at which TCI settings were changed are indicated by vertical dashed lines. A bolus infusion was followed by a 10 min recovery period, after which (the first dashed line indicates the end of this phase) TCI targets were increased in a stepwise fashion. HR, heart rate; MAP, mean arterial pressure; TCI, target-controlled infusion.
British Journal of Anaesthesia  , DOI: ( /bja/aex086)
Copyright © 2017 The Author(s) Terms and Conditions

3. Fig 2
Change in mean arterial pressure (continuous blue line) and heart rate (dashed black line) for a typical 20-yr-old individual, as a function of the respective effect-site concentrations. Ce, effect-site concentration; HR, heart rate; MAP, mean arterial pressure.
British Journal of Anaesthesia  , DOI: ( /bja/aex086)
Copyright © 2017 The Author(s) Terms and Conditions

4. Fig 3
Influence of dexmedetomidine dose (top panels) and infusion duration (lower panels) on mean arterial pressure (left panels) and heart rate (right panels) for short (30 min at most) infusions. BaseHR, baseline heart rate; BaseMAP, baseline mean arterial pressure.
British Journal of Anaesthesia  , DOI: ( /bja/aex086)
Copyright © 2017 The Author(s) Terms and Conditions

5. Fig 4
Post hoc predicted change in BIS (top panels) and probability for loss of MOAA/S 3 (bottom panels) as a function of the simultaneous change in heart rate (left panels) and mean arterial pressure (right panels). The individually predicted trajectories for all subjects are shown with green continuous lines. The population average trajectory is shown with a thick continuous blue line. Clinically interesting targets for BIS and probability for loss of MOAA/S 3 are shown with grey shaded areas. BIS, bispectral index; HR, heart rate; MAP, mean arterial pressure; MOAA/S, Modified Observer's Assessment of Alertness/Sedation; Pr, predicted.
British Journal of Anaesthesia  , DOI: ( /bja/aex086)
Copyright © 2017 The Author(s) Terms and Conditions