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Altered amphiregulin expression induced by diverse luteinizing hormone receptor reactivity in granulosa cells affects IVF outcomes  Ying Huang, Yue Zhao,

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Presentation on theme: "Altered amphiregulin expression induced by diverse luteinizing hormone receptor reactivity in granulosa cells affects IVF outcomes  Ying Huang, Yue Zhao,"— Presentation transcript:

1 Altered amphiregulin expression induced by diverse luteinizing hormone receptor reactivity in granulosa cells affects IVF outcomes  Ying Huang, Yue Zhao, Yang Yu, Rong Li, Shengli Lin, Chunmei Zhang, Ping Liu, Jie Qiao  Reproductive BioMedicine Online  Volume 30, Issue 6, Pages (June 2015) DOI: /j.rbmo Copyright © Terms and Conditions

2 Figure 1 Correlation between the amphiregulin (AREG) mRNA level in mural granulosa cells and IVF outcomes. (A) AREG expression level is positively correlated with the number of oocytes retrieved; (B) metaphase II oocytes; and (C) good-quality embryos. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © Terms and Conditions

3 Figure 2 Correlation between the amphiregulin (AREG) mRNA level in cumulus granulosa cells and IVF outcomes. The level of AREG expression is positively correlated with (A) the number of oocytes retrieved; (B) metaphase II oocytes; (C) two pronuclei zygotes; and (D) good-quality embryos. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © Terms and Conditions

4 Figure 3 Amphiregulin (AREG) and epiregulin (EREG) expression changes in mural granulosa cells after human chorionic gonadotrophin (HCG) stimulation. (A) mRNA expression level of AREG and EREG in mural granulosa cells followed by HCG at the indicated times. The data were shown as fold-change compared with the control (0 h) (mean ± SD); (B) comparison of fold-changes of AREG and EREG expression at 4 h after the HCG stimulation between the pregnant and non-pregnant groups (mean ± SD) (*P < 0.05 versus the non-pregnant group); (C) the increase of AREG expression at 4 h after stimulation was positively correlated with the number of good quality embryos (P < 0.05). Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © Terms and Conditions

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