Presentation is loading. Please wait.

Presentation is loading. Please wait.

TGF-β signaling and collagen deposition in chronic rhinosinusitis

Published byAbner Ward Modified over 5 years ago

Similar presentations

Presentation on theme: "TGF-β signaling and collagen deposition in chronic rhinosinusitis"— Presentation transcript:

1 TGF-β signaling and collagen deposition in chronic rhinosinusitis
Nicholas Van Bruaene, MD, Lara Derycke, PhD, Claudina Angela Perez-Novo, PhD, Philippe Gevaert, MD, PhD, Gabriele Holtappels, Natalie De Ruyck, Claude Cuvelier, MD, PhD, Paul Van Cauwenberge, MD, PhD, Claus Bachert, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 2, Pages e2 (August 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 ELISA measurements for TGF-β 1 and 2, expressed as pg/mL. Tissue homogenates were prepared from control tissue (inferior turbinate), CRSsNP, and CRSwNP. CON, Controls. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 TGF-β RI, II, and III mRNA expression measured by means of RT-PCR in controls, CRSsNP, and CRSwNP. Data are expressed normalized relative expression units/30 ng cDNA. CON, Controls. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Immunostaining for TGF-β 1 (A-C) and 2 (D-F) and TGF-β RI (G-I) and II (J-L) in controls, CRSsNP, and CRSwNP. Epithelium, basal membrane, and subepithelial region are shown at a final magnification of 400×. Con, Controls. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Immunostaining for pSmad 2 in controls (A and D), CRSsNP (B and E), and CRSwNP (C and F). Positive intranuclear staining is indicated by an arrow. Picrosirius red stainings for collagen in controls, CRSsNP, and CRSwNP, first viewed in bright-field microscopy (G-I), and viewed under polarized light (J-L) to assess fiber thickness. Con, Controls. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 A, Quantification by means of image analysis of the number of pSmad 2–positive cells in controls, CRSsNP, and CRSwNP. B, Quantification by means of image analysis of total collagen content in controls, CRSsNP, and CRSwNP. CON, Controls. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "TGF-β signaling and collagen deposition in chronic rhinosinusitis"

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,
Staphylococcus aureus sensitization and allergic disease in early childhood: Population- based birth cohort study  Aida Semic-Jusufagic, MD, Claus Bachert,

Staphylococcus aureus sensitization and allergic disease in early childhood: Population- based birth cohort study  Aida Semic-Jusufagic, MD, Claus Bachert,
Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B
Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo  Eli O. Meltzer, MD, Claus Bachert,

Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo  Eli O. Meltzer, MD, Claus Bachert,
Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3  Feng Lan, MD, Nan Zhang,

Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3  Feng Lan, MD, Nan Zhang,
Russell S. Traister, MD, PhD, Crystal E. Uvalle, BS, Gregory A

Russell S. Traister, MD, PhD, Crystal E. Uvalle, BS, Gregory A
Endotype-driven care pathways in patients with chronic rhinosinusitis

Endotype-driven care pathways in patients with chronic rhinosinusitis
Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3  Feng Lan, MD, Nan Zhang,

Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3  Feng Lan, MD, Nan Zhang,
The antimicrobial protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is differentially modulated in eosinophilic and noneosinophilic chronic.

The antimicrobial protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is differentially modulated in eosinophilic and noneosinophilic chronic.
Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois  Bruce K. Tan, MD, MS, Aiko I. Klingler, PhD,

Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois  Bruce K. Tan, MD, MS, Aiko I. Klingler, PhD,
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis  Hyun-Woo Shin, MD, PhD, Dong-Kyu Kim, MD, Min-Hyun Park, MD,

IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis  Hyun-Woo Shin, MD, PhD, Dong-Kyu Kim, MD, Min-Hyun Park, MD,
Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B
Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese  Ping-Ping Cao, MD, Hua-Bin Li, MD, PhD, Bao-Feng.

Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese  Ping-Ping Cao, MD, Hua-Bin Li, MD, PhD, Bao-Feng.
Increased TGF-β2 in severe asthma with eosinophilia

Increased TGF-β2 in severe asthma with eosinophilia
Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation 

Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation 
Oral steroids and doxycycline: Two different approaches to treat nasal polyps  Thibaut Van Zele, MD, PhD, Philippe Gevaert, MD, PhD, Gabriele Holtappels,

Oral steroids and doxycycline: Two different approaches to treat nasal polyps  Thibaut Van Zele, MD, PhD, Philippe Gevaert, MD, PhD, Gabriele Holtappels,
Obesity impairs apoptotic cell clearance in asthma

Obesity impairs apoptotic cell clearance in asthma
Chronic rhinosinusitis in Asia

Chronic rhinosinusitis in Asia
Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3  Se Jin Park,

Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3  Se Jin Park,

Similar presentations

Ads by Google