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Perioperative hyperinsulinaemic normoglycaemic clamp causes hypolipidaemia after coronary artery surgery†   C.J. Zuurbier, F.J. Hoek, J. van Dijk, N.G.

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Presentation on theme: "Perioperative hyperinsulinaemic normoglycaemic clamp causes hypolipidaemia after coronary artery surgery†   C.J. Zuurbier, F.J. Hoek, J. van Dijk, N.G."— Presentation transcript:

1 Perioperative hyperinsulinaemic normoglycaemic clamp causes hypolipidaemia after coronary artery surgery†   C.J. Zuurbier, F.J. Hoek, J. van Dijk, N.G. Abeling, J.C.M. Meijers, J.H.M. Levels, E. de Jonge, B.A. de Mol, H.B. Van Wezel  British Journal of Anaesthesia  Volume 100, Issue 4, Pages (April 2008) DOI: /bja/aen018 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Time course of mean (sem) plasma free fatty acids (a; FFA) and triglycerides (b) concentrations in the control (n=21) and clamp (n=23) groups. The hyperinsulinaemic normoglycaemic clamp period is indicated by the horizontal bar. AUC, area under the curve; *P<0.05 within-group compared with baseline. British Journal of Anaesthesia  , DOI: ( /bja/aen018) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Time course of mean (sem) plasma lipoprotein-triglycerides concentrations (n=12 per group) for the main lipoprotein classes VLDL (a), LDL (b), and HDL (c) in the control and clamp groups. The hyperinsulinaemic normoglycaemic clamp period is indicated by the horizontal bar. AUC, area under the curve; *P<0.05 within-group compared with baseline. British Journal of Anaesthesia  , DOI: ( /bja/aen018) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Time course of mean (sem) plasma acetoacetate (a) and β-hydroxybutyrate (b) concentrations in the control (n=21) and clamp (n=23) groups. The hyperinsulinaemic normoglycaemic clamp period is indicated by the horizontal bar. AUC, area under the curve; *P<0.05 within-group compared with baseline. British Journal of Anaesthesia  , DOI: ( /bja/aen018) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Time course of mean (sem) plasma lactate concentrations in the control (n=21) and clamp (n=23) groups. The hyperinsulinaemic normoglycaemic clamp period is indicated by the horizontal bar. AUC, area under the curve; *P<0.05 within-group compared with baseline. British Journal of Anaesthesia  , DOI: ( /bja/aen018) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

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