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Cancer Metabolism: Is Glutamine Sweeter than Glucose?

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1 Cancer Metabolism: Is Glutamine Sweeter than Glucose?
Weiqin Lu, Helene Pelicano, Peng Huang  Cancer Cell  Volume 18, Issue 3, Pages (September 2010) DOI: /j.ccr Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 Effect of Oncogenic Signals on Glutamine Metabolism through Regulation of Glutaminase The interconnection between glutamine metabolism and glucose metabolism is also shown. Inhibition of glutaminase by compound 968 suppresses oncogenic transformation induced by Rho GTPases. GLS, glutaminase; TCA cycle, tricarboxylic acid cycle; MRC, mitochondrial respiratory chain; V, mitochondrial respiratory complex V; OAA, oxaloacetate; Asp, aspartate; α-KG, α-ketoglutarate. Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2010 Elsevier Inc. Terms and Conditions

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