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Figure 3 Transport activity of human SLC25A4 and SLC25A4 p.Lys33Gln

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Presentation on theme: "Figure 3 Transport activity of human SLC25A4 and SLC25A4 p.Lys33Gln"— Presentation transcript:

1 Figure 3 Transport activity of human SLC25A4 and SLC25A4 p.Lys33Gln
Transport activity of human SLC25A4 and SLC25A4 p.Lys33Gln Transport of [14C]-labeled ADP into vesicles of L. lactis membranes expressing (A) an empty vector control, (B) SLC25A4, or (C) SLC25A4 p.Lys33Gln in the presence (black symbols) or absence (white symbols) of 20 µM carboxyatractyloside. Transport was initiated by the addition of 5 µM [14C]-ADP and was terminated by filtration and washing at the indicated time intervals. The data are represented by the average and SD of 4 assays. (D) Expression levels of wild type and p.Lys33Gln determined by western blot analysis. (E) Transport rate of the empty vector control, human SLC25A4, and p.Lys33Gln, corrected for background binding. AAC = ADP/ATP carrier; ADP = adenosine diphosphate; ATP = adenosine triphosphate. Martin S. King et al. Neurol Genet 2018;4:e256 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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