1. Adrenocorticosteroids [ə,dri:nəu,kɔ:tikəu'stiərɔid]
Chapter 30
Adrenocorticosteroids
[ə,dri:nəu,kɔ:tikəu'stiərɔid]
肾上腺皮质激素类药
Shutcm-MBL 1

2. 下丘脑 垂体 肾上腺 Control of secretion of glucocorticoids
Kidney with adrenal gland
Mineralocorticoid
[,minərələu'kɔ:tikɔid]
盐皮质激素
Glucocorticoid
肾上腺
[,ɡlu:kəu'kɔ:tikɔid]
糖皮质激素
Control of secretion of glucocorticoids
Shutcm-MBL

3. Shutcm-MBL

4. Physiological actions of glucocorticoids
Actions of glucocorticoids at doses corresponding to normal daily production levels
1 Metabolic effects on carbohydrate (increase serum glucose levels), protein (decrease protein synthesis and increase protein breakdown) , and lipid metabolism (redistribution of body fat);
2 Maintenance of fluid and electrolyte balance;
3 Preservation of normal function of the cardiovascular system, the immune system, the kidney, skeletal muscle, the endocrine system, and the nervous system.
Shutcm-MBL

5. Pharmacological actions of glucocorticoids
Effects seen only at doses exceeding the normal daily production of glucocorticoids
1. Anti- inflammatory actions
Characteristics
① inhibit all kinds of inflammatory responses (radiant, mechanical, chemical, infectious, and immunological inflammation);
② suppress either acute or chronic inflammations; inhibit the formation of cicatrice ['sikətris]伤痕；[皮肤]瘢痕;
③ induce or aggravate infection and affect healing of wound.
Shutcm-MBL

6. Pathophysiological process of inflammation
Infection
Inflammatory cell chemotaxis
[,kemə‘tæksis] 趋化
Release of inflammatory mediators like IL, NO, PGs, TNF-α
vasodilatation
Injury and repair
acute inflammation
chronic inflammation

7. • Inhibition of phospholipase A2 [fɔsfəu'laipeis]磷脂酶;
Mechanisms:
• Inhibition of phospholipase A2 [fɔsfəu'laipeis]磷脂酶;
• Stabilize the membranes of lysosome[‘laisəsəum]溶酶体;
• Reduce the production and release of inflammatory mediators;
• Reduce the number and activity of circulating immunocytes；
• reduce capillary permeability
• Decrease activity of fibroblasts
Shutcm-MBL

8. Animal cell Cell membrane Lysosome Golgi apparatus Nucleolus
Microtubule
Nucleus
Mitochondria
Smooth
endoplasmic
reticulum
Centrosome
Ribosome
Rough
endoplasmic
reticulum
Vacuole
Cytoplasm

9. Shutcm-MBL

10. 2. Immunosuppression and anti-anaphylaxis [ænəfi'læksis]
Mechanisms:
• Suppress immune responses
Reduce the production and functions of
lymphocytes
Inhibit complement system
• Stabilize the membranes of cells
• Reduce the production and release of anaphylactic mediators
过敏性反应
Shutcm-MBL

11. • Enhance myocardial contraction, increase cardiac output;
4. Anti-shock
• Enhance myocardial contraction, increase cardiac output;
• Improve microvascular circulation; decrease capillary permeability;
• Stabilize lysosomal membranes, reduce the production of myocardia-depressant factor (MDF).
Shutcm-MBL

12. 5. Effects on the bone marrow
• increase the number of red blood cells, hemoglobin, platelets;
• decrease the number of lymphocytes (T and B cells)
6. Others
• central excitation;
• increase the section of gastric acid and pepsin, promote digestion
Shutcm-MBL

13. Clinical uses 1. Substitution therapy: adrenal cortical insufficiency;
2. Severe bacterial infections or inflammation: combined with adequate antibiotics;
3. Autoimmune disorders and allergic disorders;
4. Shocks: such as infective intoxicated shock, anaphylactic shock, cardiogenic shock;
5. Hematologic diseases
6. Local application: skin diseases
[,ænəfi‘læktik] 过敏性的
[,hemə‘tɔlədʒikəl] 血液的
Shutcm-MBL

14. Adverse reactions
1. Induced by using GC with large doses or for long time
a. Cushing’s syndrome:
Shutcm-MBL

15. b. Induce or exacerbate peptic ulcers; c. Glaucoma, cataracts;
d. Growth retardation in children;
e. Sodium and fluid retention with edema;
f . Osteoporosis
2. Induced by withdrawal of therapy rapidly or abruptly:
rebound syndromes or drugs stop syndromes
Shutcm-MBL

16. Contraindications peptic ulcer
Glucocorticoids must be used with great caution in patients with
peptic ulcer
heart disease or hypertension with heart failure
certain infectious illnesses such as varicella
tuberculosis [tju:,bə:kju‘ləusis]结核病
psychoses [saɪ‘kəusiz]精神病
diabetes,
osteoporosis [,ɔstiəupə'rəusis]骨质疏松症
glaucoma
[‘peptik] 消化的/消化器官的
[,væri'selə]水痘
Shutcm-MBL

17. Therapeutic course and doses
Pulse therapy with higher glucocorticoid doses: could stop abruptly;
To diminish HPA axis suppression:
1) the steroid preparations should be given in the morning as a single dose.
2) alternate-day therapy
shutcm

18. 大纲要求
掌握糖皮质激素类药物的作用、用途、不良反应。
了解用药方法与禁忌症。
shutcm

19. 思考题 从以下病症中分别选出糖皮质激素的适应症和禁忌证，并说明相应的理由 结核性脑膜炎 肾病综合征 癫痫 活动性十二指肠溃疡 血小板减少症
结核性脑膜炎 肾病综合征 癫痫
活动性十二指肠溃疡 血小板减少症
严重高血压 中毒性菌痢 骨质疏松
shutcm