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Degree of carotid plaque calcification in relation to symptomatic outcome and plaque inflammation  Wael E Shaalan, MD, Hongwei Cheng, MD, PhD, Bruce Gewertz,

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Presentation on theme: "Degree of carotid plaque calcification in relation to symptomatic outcome and plaque inflammation  Wael E Shaalan, MD, Hongwei Cheng, MD, PhD, Bruce Gewertz,"— Presentation transcript:

1 Degree of carotid plaque calcification in relation to symptomatic outcome and plaque inflammation 
Wael E Shaalan, MD, Hongwei Cheng, MD, PhD, Bruce Gewertz, MD, James F McKinsey, MD, Lewis B Schwartz, MD, Daniel Katz, MD, Dindcai Cao, PhD, Tina Desai, MD, Seymour Glagov, MD, Hisham S Bassiouny, MD  Journal of Vascular Surgery  Volume 40, Issue 2, Pages (August 2004) DOI: /j.jvs

2 Fig 1 Spiral computed tomography cross-section images of plaques with variable degrees of calcification. Calcification area was measured with computer-assisted morphometry with color density scale analysis (calcified regions in the range vs noncalcified regions in the range). Journal of Vascular Surgery  , DOI: ( /j.jvs )

3 Fig 2 A, Histopathologic section of an asymptomatic plaque with extensive calcification. B, Region of calcification was quantitated in each section. (H&E; original magnification ×40.) L, Lumen; Ca, calcification; FC, fibrous cap. Journal of Vascular Surgery  , DOI: ( /j.jvs )

4 Fig 3 Macrophage infiltration (arrowheads) in fibrous cap region overlying the necrotic core in immunohistochemical stained section at high-power field. (Original magnification ×200.) Arrows point to immunostained macrophages. NC, Necrotic core. Journal of Vascular Surgery  , DOI: ( /j.jvs )

5 Fig 4 Receiver operating characteristic (ROC) curve for differentiating between asymptomatic and symptomatic groups on the basis of percent area calcification. Cutoff point of 30% (arrows) yielded the highest sensitivity and specificity. Journal of Vascular Surgery  , DOI: ( /j.jvs )

6 Fig 5 Correlation between mean macrophage count and percent area calcification was −0.78 (P < .0001) for symptomatic plaques and −0.89 (P < .0001) for asymptomatic plaques, indicative of the strong negative association between macrophage count and percent area calcification. Journal of Vascular Surgery  , DOI: ( /j.jvs )

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