1. Progestins Progest-4-ene-3,20-dione Progesterone 4/13/2019
MEDC 603 Steroids

2. Inhibits follicular maturation and ovulation
Functions of Progesterone
Maintains pregnancy
Inhibits follicular maturation and ovulation
prevents spontaneous uterine contraction
4/13/2019
MEDC 603 Steroids

3. Progesterone Biosynthesis and Metabolism
Cholesterol Pregnenolone Progesterone R = CH2CH2CH2CH(CH3)2
6a-hydroxy progesterone a/b-hydroxy progesterone
5b-pregnane-diol
4/13/2019
MEDC 603 Steroids

4. Progesterone Agonists
Derivatization in rings A, B and D
17a-hydroxy progesterone
caproate
Megestrol
acetate
Medroxyprogesterone
acetate
Chlormadinone
acetate
4/13/2019
MEDC 603 Steroids

5. Progesterone Agonists
Testosterone Derivatives
Ethisterone
Dimethisterone
4/13/2019
MEDC 603 Steroids

6. Progesterone Agonists
19-Nortestosterone Derivatives
Norethisterone
Norethindrone
Norethynodrel
Desogestrel
Norgestimate
Norgestrel
3-Ketodesogestrel
Ethynodiol diacetate
4/13/2019
MEDC 603 Steroids

7. Progesterone Antagonist
Mifepristone
Onapristone
4/13/2019
MEDC 603 Steroids