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Impaired vasoreactivity despite an increase in plasma nitrite in patients with abdominal aortic aneurysms  Brian S. Knipp, MS, David A. Peterson, BA,

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Presentation on theme: "Impaired vasoreactivity despite an increase in plasma nitrite in patients with abdominal aortic aneurysms  Brian S. Knipp, MS, David A. Peterson, BA,"— Presentation transcript:

1 Impaired vasoreactivity despite an increase in plasma nitrite in patients with abdominal aortic aneurysms  Brian S. Knipp, MS, David A. Peterson, BA, Sanjay Rajagopalan, MD, Christine Kehrer, MS, John W. Ford, BA, Louis G. D'Alecy, PhD, Steven E. Whitesall, BS, Matthew J. Eagleton, MD, Thomas W. Wakefield, MD, Peter K. Henke, MD, Lloyd A. Jacobs, MD, Lazar J. Greenfield, MD, James C. Stanley, MD, Gilbert R. Upchurch, MD  Journal of Vascular Surgery  Volume 35, Issue 2, Pages (February 2002) DOI: /mva Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

2 Fig. 1 After reactive hyperemia, flow mediated diameter ratio (FMDR) of patients with abdominal aortic aneurysms (AAAs) was significantly less (P =.02) than that of healthy controls. FMDR of patients with peripheral arterial occlusive disease (PAOD) was less than that of healthy controls, but difference was not statistically significant (P =.41). B, After administration of nitroglycerine, FMDR of patients with AAAs was significantly less (P =.03) than that of healthy controls. FMDR of patients with PAOD was less than that of healthy controls, but difference was not statistically significant (P =.15). Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

3 Fig. 2 Serum nitric oxide (NOx) levels in patients with an abdominal aortic aneurysm (AAA) were significantly higher than those in healthy controls (P =.01) and in patients with peripheral arterial occlusive disease (PAOD; P =.01). There was no significant difference in serum NOx levels between patients with PAOD and healthy controls (P =.74). Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

4 Fig. 3 Serum asymmetric dimethylarginine (ADMA) levels in patients with an abdominal aortic aneurysm (AAA) were decreased 26% as compared with those of patients with peripheral arterial occlusive disease (PAOD), although this decrease was not stastitically significant (P =.30). Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

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