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Chromosomal Abnormalities in Non-Small Cell Lung Carcinomas and in Bronchial Epithelia of High-Risk Smokers Detected by Multi-Target Interphase Fluorescence.

Published byΑγάθη Μαυρογένης Modified over 5 years ago

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Presentation on theme: "Chromosomal Abnormalities in Non-Small Cell Lung Carcinomas and in Bronchial Epithelia of High-Risk Smokers Detected by Multi-Target Interphase Fluorescence."— Presentation transcript:

1 Chromosomal Abnormalities in Non-Small Cell Lung Carcinomas and in Bronchial Epithelia of High-Risk Smokers Detected by Multi-Target Interphase Fluorescence in Situ Hybridization  Maura Santos Romeo, Irina A. Sokolova, Larry E. Morrison, Chan Zeng, Anna E. Barón, Fred R. Hirsch, York E. Miller, Wilbur A. Franklin, Marileila Varella-Garcia  The Journal of Molecular Diagnostics  Volume 5, Issue 2, Pages (May 2003) DOI: /S (10)60459-X Copyright © 2003 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

2 Figure 1 FISH patterns identified with the LAVysion probe. Sequences from chromosome 5p15.2 are labeled in green, from 6p11-q11 in aqua, from 7p12 in red and from 8q24 in yellow. A: Nuclei from normal lung showing diploid pattern 2222 (2 copies of each target). B: Nucleus with pattern 7687 in BAC4. C: 7p12 (EGFR) amplification in BAC1. D: Bronchial nuclei with abnormal tetrasomic pattern 4444 from P14-RML. E: Aneusomic pattern 4433 in a bronchial cell from P35. F: Aneusomic pattern 2244 indicating gain of 7p12 and 8q24 sequences in a nuclei found in sputum from a SCC patient. The Journal of Molecular Diagnostics 2003 5, DOI: ( /S (10)60459-X) Copyright © 2003 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

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