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Serum cystatin C is an easy to obtain biomarker for the onset of renal impairment in heart transplant recipients  Daniela Kniepeiss, MD, Doris Wagner,

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Presentation on theme: "Serum cystatin C is an easy to obtain biomarker for the onset of renal impairment in heart transplant recipients  Daniela Kniepeiss, MD, Doris Wagner,"— Presentation transcript:

1 Serum cystatin C is an easy to obtain biomarker for the onset of renal impairment in heart transplant recipients  Daniela Kniepeiss, MD, Doris Wagner, MD, Gerhard Wirnsberger, MD, Regina E. Roller, MD, Andrä Wasler, MD, Florian Iberer, MD, Karl-Heinz Tscheliessnigg, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 140, Issue 3, Pages (September 2010) DOI: /j.jtcvs Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Comparison of the courses of the 3 prognostic systems. SCr and GFR calculated by the MDRD formula are seen to simulate normal kidney function for more than half of the patients at all time points. MDRD, Modification of Diet in Renal Disease. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 There is a strong correlation (r = 0.886; P = .0001) between sCr and serum cystatin C after the 48-month observation period. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Serum cystatin C shows a high sensitivity and specificity (AUROC = 0.96) with a confidence interval of to and a significance of P = .0001 for the long-term prognosis of renal failure after HTx. AUROC, Area under the receiver operating characteristic; CI, confidence interval. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions


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