1. Volume 9, Issue 6, Pages 1152-1154 (June 2002)
Big G, Little G 
Louis M Luttrell 
Molecular Cell 
Volume 9, Issue 6, Pages (June 2002)
DOI: /S (02)

2. Figure 1 Rho Activation by Heterotrimeric G Proteins
Activation of heterotrimeric G proteins generates free Gαq/12/13 and Gβγ subunits, which mediate the membrane recruitment and activation of Csk. The Gβγ subunit effect involves the physical association of Gβγ and Csk, while the Gαq/12/13 effect is mediated through as yet unknown intermediates. Csk activates Rho either by relieving the Rho inhibition that is caused by Src-mediated activation of p190RhoGAP or by alternative mechanisms, possibly including activation of a RhoGEF.
Molecular Cell 2002 9, DOI: ( /S (02) )