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The pathobiology of peritonitis

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1 The pathobiology of peritonitis
John C. Hall*, Kathryn A. Heel*, John M. Papadimitriou‡, Cameron Platell*  Gastroenterology  Volume 114, Issue 1, Pages (January 1998) DOI: /S (98) Copyright © 1998 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Scanning electron micrograph of murine visceral mesothelium. Note the polygonal periphery of the closely apposed mesothelial cells and the presence of many microvilli on their coelomic surface (original magnification 1500×). Courtesy of Dr. S. Mutsaers. Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Transmission electron micrograph of human visceral mesothelium. Note the attenuated appearance of the mesothelial cells and the presence of long, wavy microvilli on their free surface (original magnification 14,000×). Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

4 Fig. 3 Scanning electron micrograph of a murine mesothelial cell and an adjacent stoma (arrow). Many microvilli can be seen on the surface of the mesothelial cells (original magnification 27,000×). Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

5 Fig. 4 Transmission electron micrograph of a stoma in human mesothelium. Only a few flattened mesothelial cell processes mark the site of the stoma, whereas the basal lamina is fragmented. A stromal macrophage (arrow) can be seen in the vicinity of the stoma (original magnification 15,000×). Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

6 Fig. 5 Transmission electron micrograph of a murine “milky spot.” Aggregates of lymphocytes and macrophages are present near two small blood vessels (original magnification 4000×). Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

7 Fig. 6 Schematic diagram showing mesothelial cell response to cytokines. ICAM-1, intercellular adhesion molecule 1; MCP, monocyte chemoattractant protein; PAI-1, plasminogen activator inhibitor 1; VCAM-1, vascular cell adhesion molecule 1. Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

8 Fig. 7 Scanning electron micrograph of an area of traumatic peritonitis in a mouse. Note an aggregate of inflammatory cells (arrow) in a denuded area (original magnification 3000×). Courtesy of Dr. S. Mutsaers. Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

9 Fig. 8 Transmission electron micrograph of an area of traumatic peritonitis in a mouse. Several macrophages can be seen on the denuded surface (original magnification 5400×). Courtesy of Dr. S. Mutsaers. Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions


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