1. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
How Scientific Is placebo Use?
Jun Ishigooka, MD, PhD
Department of Psychiatry,
Kitasato University School of Medicine
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

2. Scientific Issues in Placebo Use
“the Law of Initial Value”
Different Placebo Responses in a Single Disorder
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

3. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
Scientific Issues in Placebo Use
“the Law of Initial Value”
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

4. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
Conventional
Main Effect Model
b. Alternative
Interaction Model
(Fisher S et al, 1965)
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

5. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
Panic Disorder (1)
(Uhlenhuth EH et al, 1997)
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

6. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
Panic Disorder (2)
(Uhlenhuth EH et al, 1997)
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

7. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
Panic Disorder (3)
(Uhlenhuth EH et al, 1997)
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

8. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

9. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
Rating Scales for Symptoms
---Manner of Drug / Placebo Response???
---Surrogate Endpoint
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

10. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
Scientific Issues in Placebo
2. Different Placebo Responses in a Single Disorder
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

11. Placebo Responses in Antidepressants
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

12. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

13. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
Indicators for Melancholia
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

14. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium
Major Depression
2019/4/14
Jun Ishigooka_the 3rd Kitasato-Harvard Symposium