1. CpG Oligonucleotides Elicit Antitumor Responses in a Human Melanoma NOD/SCID Xenotransplantation Model 
Clemens Krepler, Volker Wacheck, Sabine Strommer, Gunther Hartmann, Peter Polterauer, Klaus Wolff, Hubert Pehamberger, Burkhard Jansen 
Journal of Investigative Dermatology 
Volume 122, Issue 2, Pages (February 2004)
DOI: /j X x
Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Growth of human melanoma xenotransplants in NOD/SCID mice. Therapy with CpG ODN or saline solution was started on day 5 after tumor inoculation, with subcutaneous injections three times a week until day 33. Mean±SD, n=6.
Journal of Investigative Dermatology  , DOI: ( /j X x)
Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Immunohistology of draining lymph nodes. (a), (b) stained with CD205 (DEC-205, Ly-75) for DC (a) of CpG-ODN-treated animals and (b) of saline-treated animals; (c), (d) stained using mLangerin antibodies for Langerhans-cell-derived DC (c) of CpG-ODN-treated animals and (d) of saline-treated animals. Scale bars: 50 μm.
Journal of Investigative Dermatology  , DOI: ( /j X x)
Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

4. Figure 3
Peripheral blood serum levels of IL-12. (a) after 1 wk of treatment, mean±SD, n=3; (b) after 4 wk of treatment, pooled samples, n=6.
Journal of Investigative Dermatology  , DOI: ( /j X x)
Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

5. Figure 4
Microphage infiltration in tumors. Tumor tissue after 1 wk of treatment, stained with F480 antibody for macrophages: (a) saline treated (b) CpG ODN treated. Scale bar: 50 μm.
Journal of Investigative Dermatology  , DOI: ( /j X x)
Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions