1. Cytoreductive Surgery in Advanced Endometrial Cancer
Ongoing Trial – status update
Cytoreductive Surgery in Advanced Endometrial Cancer
Multicenter Retrospective Study

2. Ongoing Trial – status update
Cytoreductive Surgery in Advanced Endometrial Cancer
Multicenter Retrospective Study
Objectives 1
Document the treatment strategy adopted in oncology reference centers for patients with primary AEC; 2
Identify the predictors of survival;
Formulate a hypothesis for selection criteria/predictive factors for successful CRS in AEC; 3 4
Explore the feasibility of a biomolecular TGCA grouping analysis (potential subsequent prospective phase to validate).

3. Ongoing Trial – status update
Cytoreductive Surgery in Advanced Endometrial Cancer
Multicenter Retrospective Study
Eligibility
Patients with primary advanced endometrial cancer treated during the period 2005 – 2015

4. Inclusion criteria Exclusion criteria
Ongoing Trial – status update
Cytoreductive Surgery in Advanced Endometrial Cancer
Multicenter Retrospective Study
Inclusion criteria
FIGO Stage: IIIA bulky*; IIIB; IIIC1 bulky*; IIIC2 bulky*; IVA; IVB intraabdominal
* diagnosed by pre-operative imaging techniques and/or intraoperatively
Exclusion criteria
- Age > 75;
- Performance Status (ECOG) >1;
- Patients treated for strictly palliative purposes;
- Patients with second malignancies who had been treated by laparotomy or who had a therapy that could interfere with the treatment of AEC

5. Cytoreductive Surgery in Advanced Endometrial Cancer
Ongoing Trial – status update
Cytoreductive Surgery in Advanced Endometrial Cancer
Multicenter Retrospective Study
An appropriate data-base has been designed and will be available online to participating centers
Centralised analysis c/o NCI – Naples Data Center

6. Cytoreductive Surgery in Advanced Endometrial Cancer
Ongoing Trial – status update
Cytoreductive Surgery in Advanced Endometrial Cancer
Multicenter Retrospective Study
Istituto Nazionale Tumori di Napoli
Università di Bologna
Arcispedale S. Maria Nuova, Reggio Emilia
Ospedale Papa Giovanni XXIII, Bergamo
Ospedale San Raffaele, Milano
Università di Bari

7. http://www.usc-intnapoli.net Study package available on
Ongoing Trial – status update
Cytoreductive Surgery in Advanced Endometrial Cancer
Multicenter Retrospective Study
Study package available on

8. Cytoreductive Surgery in Advanced Endometrial Cancer
Ongoing Trial – status update
Cytoreductive Surgery in Advanced Endometrial Cancer
Multicenter Retrospective Study
CONTACT INFORMATION
STEFANO GREGGI, MD, PhD
Gynecologic Oncology Surgery,
Istituto Nazionale Tumori “Fondazione G. Pascale”
Via M. Semmola, 80131, Naples, Italy
Tel.: ; Fax:
­E‐mail: