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Biomanufacture of human platelets for transfusion: Rationale and approaches
Eun-ju Lee, Pankaj Godara, David Haylock Experimental Hematology Volume 42, Issue 5, Pages (May 2014) DOI: /j.exphem Copyright © Terms and Conditions
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Figure 1 Stages of bioreactor culture and cellular differentiation required for generation of platelets from CD34+ cells. The key cytokines that drive cell differentiation and ultimately platelet production at each stage are indicated. SR1 = Stemregenin-1. Experimental Hematology , DOI: ( /j.exphem ) Copyright © Terms and Conditions
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Figure 2 Scenarios for generating 5.0 x 1011 platelets from 5.0 x 106 CD34+ cells. The required conversion of CD34+ cells into mature MKs then into platelets is shown. A starting number of 5 x 106 CD34+ cells reflects a number easily obtained from one cord blood unit. Experimental Hematology , DOI: ( /j.exphem ) Copyright © Terms and Conditions
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