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Control Subjects MPHD Patients Control Subjects MPHD Patients

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Presentation on theme: "Control Subjects MPHD Patients Control Subjects MPHD Patients"— Presentation transcript:

1 Control Subjects MPHD Patients Control Subjects MPHD Patients
Fig.1 Individual peak serum GH concentrations in control subjects and in patients with MPHD for: A, ITT, B, ARG-GHRH; C, ARG-L-Dopa; D, ARG; and E, L-Dopa. Panel F depicts serum IGF-1 concentrations measured at the screening visit in the two groups. The median peak GH or IGF-1 level in each groups denoted with a bar. The upper right box in each stimulation test panel shows the time course of the mean GH response in the two groups. The dashed lines and superscripts indicate diagnostic cut-points that can be employed as follows: a, minimize misclassification of MPHD patients and control subjects; b, 95% sensitivity for GHD; and c, 95% specificity for GHD A. Insulin Tolerance Test B. Arginine-GHRH Peak Serum GH (µg/L) Peak Serum GH (µg/L) __ Median Control Subjects MPHD Patients __ Median Control Subjects MPHD Patients Abbildung mod. nach Biller, 2002

2 Control Subjects MPHD Patients Control Subjects MPHD Patients
Fig.1 Individual peak serum GH concentrations in control subjects and in patients with MPHD for: A, ITT, B, ARG-GHRH; C, ARG-L-Dopa; D, ARG; and E, L-Dopa. Panel F depicts serum IGF-1 concentrations measured at the screening visit in the two groups. The median peak GH or IGF-1 level in each groups denoted with a bar. The upper right box in each stimulation test panel shows the time course of the mean GH response in the two groups. The dashed lines and superscripts indicate diagnostic cut-points that can be employed as follows: a, minimize misclassification of MPHD patients and control subjects; b, 95% sensitivity for GHD; and c, 95% specificity for GHD C. Arginine-L-Dopa D. Arginine Peak Serum GH (µg/L) Peak Serum GH (µg/L) __ __ Median Control Subjects MPHD Patients Median Control Subjects MPHD Patients Abbildung mod. nach Biller, 2002

3 Control Subjects MPHD Patients Control Subjects MPHD Patients
Fig.1 Individual peak serum GH concentrations in control subjects and in patients with MPHD for: A, ITT, B, ARG-GHRH; C, ARG-L-Dopa; D, ARG; and E, L-Dopa. Panel F depicts serum IGF-1 concentrations measured at the screening visit in the two groups. The median peak GH or IGF-1 level in each groups denoted with a bar. The upper right box in each stimulation test panel shows the time course of the mean GH response in the two groups. The dashed lines and superscripts indicate diagnostic cut-points that can be employed as follows: a, minimize misclassification of MPHD patients and control subjects; b, 95% sensitivity for GHD; and c, 95% specificity for GHD E. L-Dopa F. Serum IGF-1 Serum IGF-1 (µg/L) Peak Serum GH (µg/L) __ __ Control Subjects MPHD Patients Median Control Subjects MPHD Patients Median Abbildung mod. nach Biller, 2002

4 GH Stimulation Test Patients with 0-1 PHD Peak Serum GH (µg/L)‏
Fig.2 Individual peak serum GH responses to each of the stimulation tests in patients with 0-1 PHD. The median for each test is denoted with an arrow Abbildung mod. nach Biller, 2002

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