1. Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex
by Alyssa I. Clay-Gilmour, Theresa Hahn, Leah M. Preus, Kenan Onel, Andrew Skol, Eric Hungate, Qianqian Zhu, Christopher A. Haiman, Daniel O. Stram, Loreall Pooler, Xin Sheng, Li Yan, Qian Liu, Qiang Hu, Song Liu, Sebastiano Battaglia, Xiaochun Zhu, AnneMarie W. Block, Sheila N. J. Sait, Ezgi Karaesmen, Abbas Rizvi, Daniel J. Weisdorf, Christine B. Ambrosone, David Tritchler, Eva Ellinghaus, David Ellinghaus, Martin Stanulla, Jacqueline Clavel, Laurent Orsi, Stephen Spellman, Marcelo C. Pasquini, Philip L. McCarthy, and Lara E. Sucheston-Campbell
BloodAdv
Volume 1(20):
September 12, 2017
© 2017 by The American Society of Hematology

2. Alyssa I. Clay-Gilmour et al. Blood Adv 2017;1:1717-1728
© 2017 by The American Society of Hematology

3. Regional plot of SNP associations with normal cytogenetic B-ALL.
Regional plot of SNP associations with normal cytogenetic B-ALL. Regional plot showing association with normal cytogenetic B-ALL in a region of chromosome 14 (rs ). The x-axis is the position on the chromosome (Mb) and y-axis is the −log10P value of the SNP association with normal cytogenetics B-ALL. Filled colors indicate linkage disequilibrium (LD), as measured by r2, with the most significant SNP (shown in purple); red shows a high degree of LD whereas blue indicates lower r2. Meta-analyses show that the T allele (MAF = 0.07) increases odds of normal cytogenetic B-ALL by over 3.5-fold compared with controls (Pmeta = 5.6 × 10−9). This association was seen only with normal cytogenetic B-ALL and not observed in other subtypes. CPSF2 is the nearest gene to the association signal.
Alyssa I. Clay-Gilmour et al. Blood Adv 2017;1:
© 2017 by The American Society of Hematology

4. Manhattan plots for SNP associations with B-ALL by age.
Manhattan plots for SNP associations with B-ALL by age. (A) Pediatric (<20 years), (B) young adults (20-40 years), and (C) older adults (>40 years). The x-axis indicates the chromosome and the y-axis is the −log10P value from meta-analyses of SNP associations with B-ALL in cohorts 1 and 2. The dashed red line indicates genome-wide significance of P > 5.0 × 10−8. The SNPs highlighted in red on chromosome 7 (pediatric) are known variants in IKZF1.
Alyssa I. Clay-Gilmour et al. Blood Adv 2017;1:
© 2017 by The American Society of Hematology

5. Regional plot of age-specific (<20, 20-40, >40 years) associations with B-ALL in IKZF1.
Regional plot of age-specific (<20, 20-40, >40 years) associations with B-ALL in IKZF1. Regional plot showing age-stratified association with B-ALL within IKZF1. The x-axis is the position on the chromosome (Mb), and y-axis is the −log10P value. The circles (older adults), diamonds (young adults) and squares (pediatric) show the P value for the SNP association with risk of B-ALL, rs Filled colors indicated the LD with the most significant SNP shown in purple. Red indicates a high degree of LD whereas blue indicates lower r2. This plot shows a significant association in pediatrics, but no evidence of association with B-ALL in young adults and older adults.
Alyssa I. Clay-Gilmour et al. Blood Adv 2017;1:
© 2017 by The American Society of Hematology

6. Regional plot of sex-specific associations with B-ALL in IKZF1.
Regional plot of sex-specific associations with B-ALL in IKZF1. Regional plot of sex-specific associations with B-ALL in the IKZF1 region. The x-axis is the position on the chromosome (Mb), and y-axis is the −log10P value. The squares (male) and circles (female) show the P value for the SNP association with risk of B-ALL. Filled colors indicate the LD with the most significant SNP shown in purple. Red indicates a high degree of LD whereas blue indicates lower r2.
Alyssa I. Clay-Gilmour et al. Blood Adv 2017;1:
© 2017 by The American Society of Hematology