1. Arginine Methylation: The Coming of Age
Roméo S. Blanc, Stéphane Richard 
Molecular Cell 
Volume 65, Issue 1, Pages 8-24 (January 2017)
DOI: /j.molcel
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2. Figure 1 Protein Arginine Methylation and Demethylation
Type I, II, and III protein arginine methyltransferases (PRMTs) generate monomethylarginine as a first step, followed by asymmetrical dimethylation (aDMA; Type I) and symmetrical dimethylation (sDMA; Type II) on the nitrogen atoms of the guanidino group. PRMT mutants can exhibit a different activity than their primary type (PRMT9C431H, PRMT1 M155A/M48L, PRMT7E181D, and PRMT7E181D/Q329A). Asterisks indicate favored substrate motif. Arginine demethylation could be done by Jumonji C domain containing proteins (JmJC) which catalyze demethylation in an oxidative fashion.
Molecular Cell  , 8-24DOI: ( /j.molcel )
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3. Figure 2
Arginine Methylation at the Crossroads of Transcriptional Regulation
Arginine methylation potentiates (green arrow) or represses (red arrow) interaction with other factors (readers) and, subsequently, other posttranslational modifications (lysine methylation and acetylation). These cross-talks regulate the activation (left) or repression (right) of transcription via enzymes that catalyze methylation on histones H3 (upper) and H4 (lower), as well as non-histone proteins involved in various signaling cascades.
Molecular Cell  , 8-24DOI: ( /j.molcel )
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4. Figure 3
Arginine Methylation Regulates Neural Stem Cell Fate during Embryogenesis
The absence of the mentioned PRTMs in the central nervous system (CNS; Nestin-cre), primary neural stem cell, or progenitors reveals that arginine methylation is critical for the establishment or the maintenance of neural lineages during embryogenesis.
Molecular Cell  , 8-24DOI: ( /j.molcel )
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5. Figure 4 PRMTs Regulate Adult Muscle Stem Cell Function
The indicated PRMTs were shown to be required for muscle stem cell regenerative function in vivo using the Pax7-cre transgenic mouse model to deplete PRMT in muscle stem cells.
Molecular Cell  , 8-24DOI: ( /j.molcel )
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6. Figure 5 Immune System Needs PRMTs to Generate Mature Cells
Depletion of indicated PRMT in hematopoietic stem cells or progenitors results in the loss of specific lineage and/or maturation in both the lymphoid and myeloid lineages.
Molecular Cell  , 8-24DOI: ( /j.molcel )
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