1. The fate of inhaled antibiotics after deposition in cystic fibrosis: How to get drug to the bug? 
Aukje C. Bos, Kimberly M. Passé, Johan W. Mouton, Hettie M. Janssens, Harm A.W.M. Tiddens 
Journal of Cystic Fibrosis 
Volume 16, Issue 1, Pages (January 2017)
DOI: /j.jcf
Copyright © 2017 European Cystic Fibrosis Society. Terms and Conditions

2. Fig. 1 Inclusion articles.
Journal of Cystic Fibrosis  , 13-23DOI: ( /j.jcf )
Copyright © 2017 European Cystic Fibrosis Society. Terms and Conditions

3. Fig. 2
Pathway of the inhaled antibiotic after deposition on the mucus layer.
After depositing in the airways, the aerosol particle needs to dissolve in the airway surface layer or mucus layer. Next, the antibiotic needs to diffuse to the site where the bacteria are located. During the diffusion process through the mucus layer the aerosol particle can bind to molecules in the mucus. Also, the oxygen level, salt content and pH of the mucus are of influence on the antibiotic efficacy. Finally, the antibiotic has to overcome barriers generated by the microorganisms.
Journal of Cystic Fibrosis  , 13-23DOI: ( /j.jcf )
Copyright © 2017 European Cystic Fibrosis Society. Terms and Conditions