1. Our group is currently studying organic photovoltaics
(polymer solar cells), quantum dots, and plasmonics
using scanning probe microscopy, optical spectroscopy,
single-molecule techniques, and Dip-Pen Nanolithography
(DPN).
We have invented techniques such as fast time-resolved
electrostatic force microscopy (trEFM) and developed
photoconductive atomic force microscopy (pcAFM). 1

2. Brief Summary
Photo-induced melting properties of DNA strands conjugated to Au particles.
Detection of DNA defect by using LSPRs. 2

3. Introduction
Mirkin et al. (1996. Nature), for the first time, demonstrated
assembling gold nanoparticles intomacroscopic materials.
applying to biodiagnostic systems
Elghanian et al.,
1997. Science
(in Chem. Rev.) 3

4. Purpose Method Realizing a stimulus responsive control by light
Asanuma et al., Angew. Chem. 4

5. Results
colorless
aggregate 5

6. Control experiments
not dehybridize 6

7. Phohtoswitchable DNA-nanoparticle conjugates also enable a unique
new form of DNA-hybridization stringency.
Before suggestion••••••
Basic investigation
Nearly linear
for small aggregation 7

8. Suggestion 8

9. Detection of single-mismatched base in a DNA strand9

10. Single-base-mismatched DNAs dehybridize by UV light irradiation.10

11. 11