1. PodNet, a protein–protein interaction network of the podocyte
Gregor Warsow, Nicole Endlich, Eric Schordan, Sandra Schordan, Ravi K. Chilukoti, Georg Homuth, Marcus J. Moeller, Georg Fuellen, Karlhans Endlich 
Kidney International 
Volume 84, Issue 1, Pages (July 2013)
DOI: /ki
Copyright © 2013 International Society of Nephrology Terms and Conditions

2. Figure 1
XPodNet. Genes are represented by nodes and interactions of the corresponding proteins by edges. Nphs1 and its interaction partners are colored in dark orange. Nodes of PodNet are colored in pale orange and nodes from STRING are gray. (a) Complete network and (b) zoom-in centered to Nphs1.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions

3. Figure 2
Podocyte core network. Largest connected component of XPodNet after removal of all nodes not known to be essential (essential genes were determined by association of human gene mutation, gene knockout in mice, or gene knockdown in zebrafish with a podocyte phenotype such as foot process effacement), which can be omitted without breaking the component apart. Red nodes represent essential genes, and other nodes are colored in blue.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions

4. Figure 3
Networks of most abundant interactions. (a) Intersection of the 50 most abundant interactions for Adult S-Pod and Adult G-Pod in XPodNet (Supplementary Figure S1 online). Pod, podocyte. The resulting network contains of 19 most abundant interactions (solid lines). Dotted lines represent interactions that are not most abundant in at least one of both intersected networks (gray line in Supplementary Figure S1 online). (b) The same procedure has been applied to the 75 most abundant interactions in GlobalNet, to also give 19 common most abundant interactions for both conditions.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions

5. Figure 4
Principal component analysis. Principal component analysis of several biological conditions (for abbreviations see Table 3) using gene expression data from the Affymetrix Mouse Genome and Affymetrix Mouse Gene 1.0 ST microarrays.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions

6. Figure 5
ExprEssence analyses for Adult G-Pod versus E13.5 G-Pod. The 10 most upregulated (red) and downregulated (green) interactions, including connecting interactions (gray), are shown for (a) XPodNet and (b) GlobalNet. The node color describes expression levels (left side, E13.5, G-Pod; right side, Adult G-Pod). The thicker an edge, the more it is upregulated/downregulated. E13.5, embryonic day 13.5; Pod, podocyte.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions

7. Figure 6
ExprEssence analyses for Prim M-Pod versus Adult G-Pod. The 10 most upregulated (red) and downregulated (green) interactions, including connecting interactions (gray), are shown for (a) XPodNet and (b) GlobalNet. The node color describes expression levels (left side, Adult G-Pod; right side, Prim M-Pod). The thicker an edge, the more it is upregulated/downregulated. Pod, podocyte; Prim, primary.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions

8. Figure 7
Scatter plots of mean log fold changes in abundance of interaction (mean ExprEssence link score). The x axis describes changes in abundance of interactions during podocyte development and the y axis describes them for in vivo podocytes that are put into culture for interactions in (a) XPodNet and (b) GlobalNet. The ellipse contains 95% of the data points.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions