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Jee Hoon Roh, David M. Holtzman  Neuron 

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Presentation on theme: "Jee Hoon Roh, David M. Holtzman  Neuron "— Presentation transcript:

1 Stealth Attack: Plaque-Specific Antibody Allows for Efficient Aβ Removal without Side Effects 
Jee Hoon Roh, David M. Holtzman  Neuron  Volume 76, Issue 5, Pages (December 2012) DOI: /j.neuron Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Aβ Plaque-Specific Antibody Removing Plaques without Increasing CAA Plaque-specific antibody mE8 removes pre-existing Aβ plaques without causing increased CAA and ARIA (right). In contrast, 3D6 antibody prevented Aβ plaque formation but could not remove pre-existing plaques in the brain (left). Insets in the left panel are reprinted from Sperling et al. (2011). CAA, cerebral amyloid angiopathy; ARIA, amyloid-related imaging abnormalities. Neuron  , DOI: ( /j.neuron ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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