1. Nonhematopoietic cells help regulate the pathogenic adaptive immune response during the second peak of joint swelling.
Nonhematopoietic cells help regulate the pathogenic adaptive immune response during the second peak of joint swelling. WT and Viperin−/− chimeric mice were generated as indicated in the figure (genotype of the mice←genotype of the bone marrow). 8 wk after bone marrow graft, the mice were infected with 1 × 106 pfu CHIKV by joint footpad inoculation. (A) Schematic representation of experimental protocol. (B) Disease score calculated as the increase of footpad height × breadth relative to day 0. The data are representative of two independent experiments (n = 10–12 mice per group) and analyzed by nonparametric Mann–Whitney t test, performed for each day between the groups indicated on the figure legend by the bar, and the significance is indicated on the figure by the * color (*P < 0.05, **P < 0.01, and ***P < 0.001).
Guillaume Carissimo et al. LSA 2019;2:e
© 2019 Carissimo et al.