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Published byΚλαύδιος Τομαραίοι Modified over 6 years ago
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Uterine rudiments in patients with Mayer-Rokitansky-Küster-Hauser syndrome consist of typical uterine tissue types with predominantly basalis-like endometrium Katharina Rall, M.D., Gianmaria Barresi, Diethelm Wallwiener, M.D., Sara Y. Brucker, M.D., Annette Staebler, M.D. Fertility and Sterility Volume 99, Issue 5, Pages (April 2013) DOI: /j.fertnstert Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 Line 1: Uterine rudiment with endometrial lining. (A) Hematoxylin and eosin (H & E) staining (×50); (B) H & E staining (×200); (C) immunohistochemistry (IHC) for CD10 demonstrating positive reaction with endometrial stroma; (D) IHC for desmin. Line 2: Uterine rudiment with tubal differentiation. (A) Secretory changes; (B) H & E staining (×200); (C) IHC for CD10 demonstrating very little reaction and lack of endometrial stroma; (D) IHC for desmin. Line 3: Uterine rudiment with proliferating endometrial lining. (A) IHC for Ki67 (MiB1) demonstrating focal proliferation (×200); (B) estrogen receptor (ER) and (C) P receptor (PR) with diffuse and strong nuclear expression; (D) IHC for CD90 showing increased staining in the functionalis-like endometrium. Line 4: Uterine rudiment with nonproliferating endometrial lining and partially decreased expression of PR. (A) IHC for Ki67 (MiB1) demonstrating low proliferative index (×200); (B) ER with strong expression; (C) PR with partially decreased expression; (D) IHC for CD90 showing endometrium of the basalis type with no CD90 staining in the stroma and only focal staining limited to perivascular cells. Line 5: Normal endometrium in proliferative phase. (A) IHC for Ki67 (MiB1) demonstrating high proliferative index; (B) ER with strong expression; (C) PR with strong expression; (D) IHC for CD90 showing increased staining in the functionalis and no staining in the basalis layer. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 Endometrial proliferative capacity in uterine rudiments compared with control tissue (proliferative phase); P<.0001 (epithelium), P=.001 (stroma). Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions
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