1. On the Assessment of Statistical Significance in Disease-Gene Discovery 
Lue Ping Zhao, Ross Prentice, Fumin Shen, Li Hsu 
The American Journal of Human Genetics 
Volume 64, Issue 6, Pages (June 1999)
DOI: /512072
Copyright © 1999 The American Society of Human Genetics Terms and Conditions

2. Figure 1
Typical pattern of estimated recombination fractions from simulated genome scan with the mixing proportions λ = 0, .25, , and 1.00 (other examples may be simulated online at the Fred Hutchinson Cancer Research Center QGE Website).
The American Journal of Human Genetics  , DOI: ( /512072)
Copyright © 1999 The American Society of Human Genetics Terms and Conditions

3. Figure 2
Typical pattern of estimated correlation coefficients from a simulated genome scan with mixing proportion λ = .75
The American Journal of Human Genetics  , DOI: ( /512072)
Copyright © 1999 The American Society of Human Genetics Terms and Conditions

4. Figure 3
Powers, reliability, TPP, and FPP, for LOD scores of 3.0 and 3.6 in the presence of one major gene.
The American Journal of Human Genetics  , DOI: ( /512072)
Copyright © 1999 The American Society of Human Genetics Terms and Conditions

5. Figure 4
Powers, reliability, TPP, and FPP, for LOD scores of 3.0 and 3.6 in the presence of two major genes.
The American Journal of Human Genetics  , DOI: ( /512072)
Copyright © 1999 The American Society of Human Genetics Terms and Conditions

6. Figure 5
Powers and reliability for LOD score of 3.6 under the one-major-gene alternative, with four key parameters varying: (a) the neighborhood parameter for the candidate genomic region is chosen to be ε = 2, 5, 10, or 20 cM; (b) the length of the chromosome is 60, 150, 200, or 300 cM; (c) η = 20, 40, 50, or 100; (d) n = 30, 50, 60, or 100.
The American Journal of Human Genetics  , DOI: ( /512072)
Copyright © 1999 The American Society of Human Genetics Terms and Conditions

7. Figure 6
Powers and reliability for LOD score 3.6 in the presence of two major genes, with four key parameters varying: (a) n = 30, 50, 60, or 100; (b) η = 20, 40, 50, or 100; (c) length of chromosome is 60, 150, 200, or 300 cM; (d) neighborhood parameter for candidate genomic region is chosen to be ε = 2, 5, 10, or 20 cM.
The American Journal of Human Genetics  , DOI: ( /512072)
Copyright © 1999 The American Society of Human Genetics Terms and Conditions

8. Figure 7
Typical pattern of LOD scores and Z-scores from a simulated genome scan with the mixing proportion λ = .05 (other examples may be simulated online at the Fred Hutchinson Cancer Research Center QGE Website).
The American Journal of Human Genetics  , DOI: ( /512072)
Copyright © 1999 The American Society of Human Genetics Terms and Conditions