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Topical head cooling during rewarming after experimental hypothermic circulatory arrest  Matti Pokela, MD, Janne Heikkinen, MS, Fausto Biancari, MD, PhD,

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Presentation on theme: "Topical head cooling during rewarming after experimental hypothermic circulatory arrest  Matti Pokela, MD, Janne Heikkinen, MS, Fausto Biancari, MD, PhD,"— Presentation transcript:

1 Topical head cooling during rewarming after experimental hypothermic circulatory arrest 
Matti Pokela, MD, Janne Heikkinen, MS, Fausto Biancari, MD, PhD, Erkka Rönkä, MS, Timo Kaakinen, MS, Vilho Vainionpää, MD, PhD, Kai T Kiviluoma, MD, PhD, Pekka Romsi, MD, Enrico Leo, MD, Jorma Hirvonen, MD, PhD, Pasi Lepola, MS, Jussi Rimpiläinen, MD, PhD, Tatu S Juvonen, MD, PhD  The Annals of Thoracic Surgery  Volume 75, Issue 6, Pages (June 2003) DOI: /S (03)

2 Fig 1 Daily score indicating behavioral recovery after 75 minutes hypothermic circulatory arrest. A score of 9 indicates essentially a complete recovery. (Left) Topical cooling group. (Right) Control group. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

3 Fig 2 Median brain temperatures in pigs during the experiment. *p less than 0.05; **p less than 0.01 difference between study groups at a certain interval. (HCA = hypothermic circulatory arrest.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

4 Fig 3 Median brain and blood temperatures (25th to 75th percentile) in both study groups during the experimental protocol. (a) Topical cooling group. (b) Control group. (HCA = hypothermic circulatory arrest.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

5 Fig 4 (a) Central venous pressure, (b) fluid balance, (c) mean arterial pressure, and (d) vascular resistance. **p less than 0.01 difference between study groups at a certain interval. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

6 Fig 5 Medians (25th to 75th percentile) of (a–e) brain microdialysis measurements and (f) intracranial pressure. (HCA = hypothermic circulatory arrest.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

7 Fig 6 Median (25th and 75th percentiles) (right) brain lactate and glucose ratio, (middle) lactate and pyruvate ratio, and (left) brain tissue O2 partial pressures. *p less than (HCA = hypothermic circulatory arrest.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

8 Fig 7 Electroencephalogram (EEG) (right) beta and (left) theta wave energy (mV2) with mean line and standard error of mean in the study groups. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

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