1. γHV68 vGAT: A Viral Pseudoenzyme Pimping for PAMPs
Daniel Kolakofsky, Dominique Garcin 
Molecular Cell 
Volume 58, Issue 1, Pages 3-4 (April 2015)
DOI: /j.molcel
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Figure 1 γΗV68 versus Host Innate Immunity
Upon entering a cell, γHV68 sends its capsid core to the nucleus (left side). One of its tegument proteins, vGAT (gray), recruits cellular PFAS (green) to auto-inhibited RIG-I (top left) where vGAT:PFAS deamidates Q10, N245, and N445 (yellow dots) to E and D (black dots). This induces CARD liberation, and activated RIG-I, which can no longer interact with 5′ ppp-dsRNA (top right), oligomerizes with ubiquitin chains and interacts with mitochondrial MAVS (right side). This activates IKKβ, which phosphorylates the RelA (p65) subunit of NF-κB, which is then ubiquitinated by viral RTA and sent for proteasomal degradation, thus blocking cytokine induction. vGAT also blocks activation of the IRF3/7 pathway and IFN induction in an unknown manner.
Molecular Cell  , 3-4DOI: ( /j.molcel )
Copyright © 2015 Elsevier Inc. Terms and Conditions