1. Toxic Effects Associated With Consumption of Zinc
Petar G. Igic, MD, Edward Lee, MD, William Harper, MD, Keith W. Roach, MD 
Mayo Clinic Proceedings 
Volume 77, Issue 7, Pages (July 2002)
DOI: /
Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions

2. Figure 1
Top, graphic representation of patient's hematocrit (Hct) and leukocyte (white blood cell [WBC]) counts (x 109/L) over time. The mode (intravenous [IV] or oral [PO]) and daily copper dose administered over time is shown at the top of the figure. Initially, 2 mg IV per day for 5 days was administered, followed by 10 mg PO per day for 10 days, and finally 2 mg PO per day for 70 days. The steep rise in Hct levels on day 7 (arrow) of hospitalization is attributed to the transfusion of 2 U of packed red blood cells. The rapid rise in WBC count at the same time is due to human granulocyte colony-stimulating factor therapy. Bottom, As expected, serum zinc and copper levels measured over 90 days return to normal with zinc discontinuation and copper supplementation.
Mayo Clinic Proceedings  , DOI: ( / )
Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions