1. Volume 154, Issue 6, Pages 1660-1671 (May 2018)
Pharmacokinetics and Exposure Response Relationships of Ustekinumab in Patients With Crohn's Disease 
Omoniyi J. Adedokun, Zhenhua Xu, Christopher Gasink, Douglas Jacobstein, Philippe Szapary, Jewel Johanns, Long-Long Gao, Hugh M. Davis, Stephen B. Hanauer, Brian G. Feagan, Subrata Ghosh, William J. Sandborn 
Gastroenterology 
Volume 154, Issue 6, Pages (May 2018)
DOI: /j.gastro
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2. Figure 1
Median serum ustekinumab concentrations illustrating dose proportionality over time during the induction studies UNITI-1 and UNITI-2.
Gastroenterology  , DOI: ( /j.gastro )
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3. Figure 2
Median serum ustekinumab concentrations over time from induction with a dose of 130 mg (A) or ∼6mg/kg (B) and through the maintenance study IM-UNITI. The patients in the placebo groups in both (A) and (B) received an IV induction dose of ustekinumab only and were on placebo treatment during maintenance. I, induction; M, maintenance.
Gastroenterology  , DOI: ( /j.gastro )
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4. Figure 3
Proportions of patients achieving clinical remission by serum ustekinumab concentration quartiles at week 8 in the UNITI-1 (A) and UNITI-2 (B) induction studies, at week 24 (C) in the IM-UNITI maintenance study, and at week 24 in the q12w (D) and q8w (E) doses in the IM-UNITI maintenance study. Patients in the placebo group received an IV induction dose of ustekinumab only and were on placebo treatment during maintenance. N, number of patients; Q, quartile.
Gastroenterology  , DOI: ( /j.gastro )
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5. Figure 4
Proportions of patients achieving endoscopic endpoints by serum ustekinumab concentration quartiles at week 44 in the IM-UNITI maintenance study. Reduction in the SES-CD score of ≥3 points (A), endoscopic response (B), and endoscopic remission (C). Average trough concentrations were obtained by computing the arithmetic mean of the observed trough concentration for each patient (q12w: week 24, week 36; q8w: week 24, week 32, and week 40) to reflect average exposure at steady state. N, number of patients; Q, quartile.
Gastroenterology  , DOI: ( /j.gastro )
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6. Figure 5
ROC curve analysis of optimal serum ustekinumab thresholds associated with clinical remission at week 8 (A) of the combined UNITI-1 and UNITI-2 induction studies, and at week 24 (B) and week 44 (C) of the IM-UNITI maintenance study. Average trough concentrations were obtained by computing the arithmetic mean of the observed trough concentration for each patient (q12w: week 24, week 36; q8w: week 24, week 32, and week 40) to reflect average exposure at steady state.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2018 AGA Institute Terms and Conditions