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Inhibition of neuronal nitric oxide synthase reduces isoflurane MAC and motor activity even in nNOS knockout mice  T Engelhardt, P.R. Lowe, H.F. Galley,

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Presentation on theme: "Inhibition of neuronal nitric oxide synthase reduces isoflurane MAC and motor activity even in nNOS knockout mice  T Engelhardt, P.R. Lowe, H.F. Galley,"— Presentation transcript:

1 Inhibition of neuronal nitric oxide synthase reduces isoflurane MAC and motor activity even in nNOS knockout mice  T Engelhardt, P.R. Lowe, H.F. Galley, N.R. Webster  British Journal of Anaesthesia  Volume 96, Issue 3, Pages (March 2006) DOI: /bja/ael010 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

2 Fig. 1 Representative gel image of typical PCR. DNA from WT mice amplifies a product of 404 bp, whereas DNA from KO mice amplifies a 603 bp product. All primers were included in every PCR hence heterozygous mice would have shown both bands. British Journal of Anaesthesia  , DOI: ( /bja/ael010) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

3 Fig. 2 The effect of 7-NI on spontaneous motor activity as (a) number of line crossings and (b) number of rearings. Open symbols are WT mice and solid symbols are KO mice. Data are displayed as median and range. *P=0.031 when compared with WT mice before injection of 7-NI. British Journal of Anaesthesia  , DOI: ( /bja/ael010) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions


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