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Association of the very early rise of human chorionic gonadotropin with adverse outcomes in singleton pregnancies after in vitro fertilization  Christopher.

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Presentation on theme: "Association of the very early rise of human chorionic gonadotropin with adverse outcomes in singleton pregnancies after in vitro fertilization  Christopher."— Presentation transcript:

1 Association of the very early rise of human chorionic gonadotropin with adverse outcomes in singleton pregnancies after in vitro fertilization  Christopher B. Morse, M.D., Kurt T. Barnhart, M.D., M.S.C.E., Suneeta Senapati, M.D., M.S.C.E., Mary D. Sammel, Sc.D., Erica C. Prochaska, B.A., Anuja Dokras, M.D., Ph.D., Charalampos Chatzicharalampous, M.D., Christos Coutifaris, M.D., Ph.D.  Fertility and Sterility  Volume 105, Issue 5, Pages e3 (May 2016) DOI: /j.fertnstert Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Linear regression of hCG rise versus birth weight in male (blue dots) and female (red x's) infants. There was a significant positive association between hCG rise and birth weight (P=.002; n = 360). Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Linear regression of hCG rise versus birth weight of singleton pregnancies after fresh embryo transfer cycles (red dots) or following frozen/thawed embryo transfer cycles (blue x's). There was a significant positive association between hCG rise and birth weight (P=.002; n = 360). Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

4 Supplemental Figure 1 Linear regressions of hCG rise versus birth weight of singleton pregnancies after (A) fresh or (B) frozen/thawed embryo transfer cycles. A statistical test for effect modification due to type of transfer (fresh vs. frozen) was not statistically significant (P=.263). Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

5 Supplemental Figure 2 Box plots of hCG rise after fresh (n = 291) versus frozen/thawed (n = 69) embryo transfer cycles stratified by cutoff points in (A) absolute hCG value and (B) number of days after egg retrieval. *P≤.0001; +P≤.01. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions


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