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Impaired humoral and cellular immune responses to influenza vaccination in chronic obstructive pulmonary disease patients  Aurélien Parpaleix, PhD, Laurent.

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Presentation on theme: "Impaired humoral and cellular immune responses to influenza vaccination in chronic obstructive pulmonary disease patients  Aurélien Parpaleix, PhD, Laurent."— Presentation transcript:

1 Impaired humoral and cellular immune responses to influenza vaccination in chronic obstructive pulmonary disease patients  Aurélien Parpaleix, PhD, Laurent Boyer, MD, Aurelie Wiedemann, PhD, Christine Lacabaratz, PhD, Laurent Margarit, MS, Vincent Enouf, PhD, Philippe Le Corvoisier, MD, PhD, Anne Lino, MD, Ala Covali-Noroc, MD, Bruno Housset, MD, PhD, Christos Chouaid, MD, PhD, Bernard Maitre, MD, PhD, Yves Lévy, MD, PhD, Jean-Daniel Lelièvre, MD, PhD, Serge Adnot, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 140, Issue 6, Pages e6 (December 2017) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Geometric mean titers (GMTs) of hemagglutination-inhibiting antibodies to A/California/07/2009, A/Texas/07/2009, and B/Massachusetts/2/2012 viral strains in patients with COPD and controls before (D0) and after (D30) vaccination. B, Gating strategy, analysis of IFN-γ+, IL-2+, and TNF-α+ CD4+ T cells among PBMCs; Luminex assay of IFN-γ, IL-2, and TNF-α (pg/mL) in supernatants of cultured PBMCs stimulated in vitro for 5 days by the whole influenza vaccine (150 ng/mL) in patients with COPD and controls. FCS-A, Forward scatter-area; NS, not significant; SSC-A, side scatter-area. ∗P < .05; ∗∗P < .01. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 Delta of geometric mean titers (GMTs) (D30 – D0) for A/California/07/2009, A/Texas/07/2009, and B/Massachusetts/2/2012 viral strains in patients with COPD and controls. NS, Not significant. ∗P < .05. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E2 CD4+ T cells and PBMCs from patients with COPD showed no differences in cytokines production in response to in vitro stimulation with cytomegalovirus lysate. A, Analysis of IFN-γ+, IL-2+, and TNF-α+ CD4+ T cells among PBMCs stimulated in vitro for 5 days by CMV lysate (5 μg/mL). B, Luminex assay of IFN-γ, IL-2, and TNF-α (pg/mL) in supernatants of cultured PBMCs stimulated in vitro for 5 days by CMV lysate. NS, Not significant (P ≥ .05). Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E3 Proliferation of T cells stimulated in vitro by the whole influenza vaccine was not altered in patients with COPD. A, CD3+, CD4+, and CD8+ T-cell proliferation was assessed by CFSE dilution of PBMCs stimulated in vitro for 5 days by the whole influenza vaccine (150 ng/mL). B, Telomere length in patients with COPD compared with healthy controls. CFSE, Carboxyfluorescein succinimidyl ester; NS, not significant (P ≥ .05). Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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