1. Impact of physiologic pacing versus right ventricular pacing among patients with left ventricular ejection fraction greater than 35%: A systematic review for the ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay 
David J. Slotwiner, MD, FACC, FHRS, Merritt H. Raitt, MD, FACC, FHRS, Freddy Del-Carpio Munoz, MD, MSc, FHRS, Siva K. Mulpuru, MD, FACC, Naseer Nasser, MD, Pamela N. Peterson, MD, MSPH, FACC 
Heart Rhythm 
DOI: /j.hrthm
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

2. Figure 1
PRISMA Diagram.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

3. Figure 2
Studies Included in the Meta-Analyses With Selected Results. Green-shaded boxes indicate that the results are statistically significant (p<0.05). Orange-shaded boxes indicate that only 2 studies reported results. BiV = biventricular; CI = confidence interval; LV = left ventricular; LVEF = left ventricular ejection fraction; MD = mean difference; NYHA = New York Heart Association; RR = relative risk; RV = right ventricular; RVP = right ventricular pacing; SF-36 = 36-Item Short-Form Health Survey.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

4. Figure 3A
Forest Plots for BiVP Versus RVP, LV End-Systolic Volume. Heterogeneity is defined as: Q (df=2)=2.28; p=0.32; I2=12.31%. BiVP = biventricular pacing; FE = fixed effects; LV = left ventricular; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

5. Figure 3B
Funnel Plot for BiVP Versus RVP, LV End-Systolic Volume. BiVP = biventricular pacing; LV = left ventricular; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

6. Figure 4A
Forest Plots for BiVP Versus RVP, LV End-Diastolic Volume. Heterogeneity is defined as: Q (df=2)=1.78; p=0.41; I2=0%. BiVP = biventricular pacing; FE = fixed effects; LV = left ventricular; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

7. Figure 4B
Funnel Plot for BiVP Versus RVP, LV End-Diastolic Volume. BiVP = biventricular pacing; LV = left ventricular; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

8. Figure 5A
Forest Plot for BiVP Versus RVP, LVEF. Heterogeneity is defined as: Q (df=2)=1.88; p=0.39; I2=0%. BiVP = biventricular pacing; FE = fixed effects; LVEF = left ventricular ejection fraction; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

9. Figure 5B
Funnel Plot for BiVP Versus RVP, LVEF. BiVP = biventricular pacing; LVEF = left ventricular ejection fraction; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

10. Figure 6A
Forest Plot for HisBP Versus RVP, LVEF. Heterogeneity is defined as: Q (df=2)=0.77; p=0.68; I2=0%. FE = fixed effects; HisBP = His bundle pacing; LVEF = left ventricular ejection fraction; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

11. Figure 6B
Funnel Plot for HisBP Versus RVP, LVEF. HisBP = His bundle pacing; LVEF = left ventricular ejection fraction; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

12. Figure 7A
Forest Plot for HisBP Versus RVP, NYHA Class. Heterogeneity is defined as: Q (df=2)= 2.79; p=0.25; I2=28.40%. FE = fixed effects; HisBP = His bundle pacing; NYHA = New York Heart Association; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

13. Figure 7B
Funnel Plot for HisBP Versus RVP, NYHA Class. HisBP = His bundle pacing; NYHA = New York Heart Association; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

14. Figure 8A
Forest Plot for BiVP and HisBP Versus RVP, LV End-Systolic Volume. Heterogeneity is defined as: Q (df=4)=2.30; p=0.68; I2=12.98%. BiVP = biventricular pacing; FE = fixed effects; HisBP = His bundle pacing; LV = left ventricular; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

15. Figure 8B
Funnel Plot for BiVP and HisBP Versus RVP, LV End-Systolic Volume. BiVP = biventricular pacing; HisBP = His bundle pacing; LV = left ventricular; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

16. Figure 9A
Forest Plot for BiVP and HisBP Versus RVP, LV End-Diastolic Volume. Heterogeneity is defined as: Q (df=4)=1.91; p=0.75; I2=0%. BiVP = biventricular pacing; FE = fixed effects; HisBP = His bundle pacing; LV = left ventricular; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

17. Figure 9B
Funnel Plot for BiVP and HisBP Versus RVP, LV End-Diastolic Volume. BiVP = biventricular pacing; HisBP = His bundle pacing; LV = left ventricular; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

18. Figure 10A
Forest Plot for BiVP and HisBP Versus RVP, LVEF. Heterogeneity is defined as: Q (df=5)=3.28; p=0.66; I2=39.11%. BiVP = biventricular pacing; FE = fixed effects; HisBP = His bundle pacing; LVEF = left ventricular ejection fraction; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions

19. Figure 10B
Funnel Plot for BiVP and HisBP Versus RVP, LVEF. BiVP = biventricular pacing; HisBP = His bundle pacing; LVEF = left ventricular ejection fraction; RVP = right ventricular pacing.
Heart Rhythm DOI: ( /j.hrthm )
Copyright © 2019 American College of Cardiology Foundation, the American Heart Association, Inc., and the Heart Rhythm Society Terms and Conditions