1. Extending Quality Assurance and Data Integrity from Laboratory to Decision Makers
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PerkinElmer Instructor Notes Day1 Part 1 1

2. OVERVIEW General Problems Solutions Manual and/or Duplicate Entry
Functionality Gaps in Process Flow
Lack of Analytical Review Knowledge
Solutions
Closing Functionality Gaps to Enhance Data Integrity
Enhancing knowledge of Quality Control Associations to Field Samples
Importance of Quality Control Frequency
Tracking professional judgments and decisions along the process flow
Result comparison reviews – do the results make sense
Result trending review – z scoring – brings anomalies to the surface
Early alert and analytical issue communication to decision makers
The agenda for today’s webinar is as follows:
First, a brief background of who we are. An overview of the Alliance. And a brief review of the Environmental Industry. Then, we’ll discuss how we’ll leverage and support of the instrument sale, marketing and communications from EISC to all of you, as well as, What some of the expectations are. And finally, we want to leave you with a few things you can do right now to increase your opportunity for the instrument sale and then we’ll open it up to any questions you may have. It’s a lot of information and I want to keep it to about mins. So, I”ll run through much of this information pretty quickly to get to the Q&A portion.
© Copyright 2017 EISC, All rights reserved. Unauthorized duplication is a violation of applicable laws.
PerkinElmer Instructor Notes Day1 Part 1 2

3. Problem: Process Gaps in the Lab Data Life Cycle
Manual and Duplicate Data Entry
Disparate Data Sources
LIMS Connection
Non-automated Quality Assurance Process
Data Gymnastics to reporting or EDDs
The agenda for today’s webinar is as follows:
First, a brief background of who we are. An overview of the Alliance. And a brief review of the Environmental Industry. Then, we’ll discuss how we’ll leverage and support of the instrument sale, marketing and communications from EISC to all of you, as well as, What some of the expectations are. And finally, we want to leave you with a few things you can do right now to increase your opportunity for the instrument sale and then we’ll open it up to any questions you may have. It’s a lot of information and I want to keep it to about mins. So, I”ll run through much of this information pretty quickly to get to the Q&A portion.
© Copyright 2017 EISC, All rights reserved. Unauthorized duplication is a violation of applicable laws.
PerkinElmer Instructor Notes Day1 Part 1 3

4. Automation Solutions to Functionality Gaps – Enhancing the labs present process
Instrument Interfacing
Notifications/
Transfer Results
Electronic Communication
Automated QA System
GCMS/LCMS
Trending Transfers
LIMS
Other Organics
Reporting
Inorganics
Bi-Directional LIMS Connection
Visualization Transfers
Other Instrument(s)
LIMS
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PerkinElmer Instructor Notes Day1 Part 1 4

5. SVOC and VOC Associations
Tune
Initial Calibrations
Continuing Calibration Verification
Method Blank
Laboratory Control Sample
Client Samples 1 - n
Matrix Spike
Matrix Spike Duplicate
Client Samples 1 – n
ICAL Assoc MB
Assoc
And
Prep QC
Sample QC
CCAL
Assoc MB
Assoc
And
Prep QC
CCAL
Assoc
Sample QC
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6. Pesticides/PCB Associations
Instrument Blank
Resolution Check
Performance Evaluation
Single Point Calibrations
Toxaphene/Chlordane Calibrations
Pesticide Initial Calibrations
Continuing Calibration
Method Blank
Laboratory Control Sample
Samples 1 – n
Matrix Spike
Matrix Spike Duplicate
Samples 1 – n …
Closing Continuing Calibration
Run Assoc
PEM
Assoc
CCAL
Assoc
Prep QC
Sample QC
Sample QC
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7. Inorganic Associations
Calibrations
Initial Calibration Verification
Initial Calibration Blanks
Quantitation Check Standard
Interference Checks
Continuing Calibration Verification
Continuing Calibration Blanks
Method Blank
Laboratory Control Sample
Samples 1 – 10
Matrix Spike
Duplicate
Serial Dilution
Post Spike
Continuing Calibration Blank
Closing QC
Run
Bracket
Prep QC
Sample QC
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8. All Laboratories – Primary, Secondary/Peer, and Completeness Reviews
GCMS
GCMS
GCMS
HPLC AA
ICPMS
LCMS
ICP GC
Quality Assurance
Primary Review
Secondary Review
Completeness Review
All issues remain internal not found by the lab’s client
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9. Result Comparison Reviews – Do the results make sense?
Low or High pH on liquid analysis
Low or High pH on Pesticides analysis
Influent vs. CABI vs. Effluent Results
Total vs. Dissolved Results
GC vs. GCMS Results
Bleed over from Dirty to Clean Samples
Continuing Calibration Blanks
Breakdowns
Tailing
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10. Consistent Concentrations Seasonal Contaminant Fluctuations
Trending – Z Scoring (brings anomalies to the surface)
Lab Data
Consistent Concentrations
Seasonal Contaminant Fluctuations
Is something different occurring with the field sample or did something go wrong during the process?
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11. Allows Decision Makers to be Proactive rather than Reactive
Key Notification Alerts - Field Samples Outside Limit
Allows Decision Makers to be Proactive rather than Reactive
Human Health is impacted
Environmental Disaster
Company Prosecution and/or Legal Case
Huge Discharge and Cleanup Fines
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12. Communication of Qualified Analytical Results is Key to Sound Decisions
GCMS
HPLC AA
ICPMS GC
LCMS
ICP
Defensibility
Compliance
Result Reliability
Sound Decisions
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13. Samples and Preparation QC (Tier 2)
Importance
Full Level (Tier 3 & 4)
Possible Liabilities
Possible Litigation
Waste Streams
Remediation
Accidents
Superfund
Samples and Preparation QC (Tier 2)
Monitoring
Compliance
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14. Conclusions Closing the Functionality Gaps
Return to your Core Competence
Enhance the Quality Assurance
Result Reliability = Sound Decisions
Questions?
Contact Information:
Paul Banfer
Ext 3
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