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Hotspot Mutation of Brahma in Non-Melanoma Skin Cancer

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1 Hotspot Mutation of Brahma in Non-Melanoma Skin Cancer
Fergal J. Moloney, J Guy Lyons, Vanessa L. Bock, Xiao X. Huang, Matthew J. Bugeja, Gary M. Halliday  Journal of Investigative Dermatology  Volume 129, Issue 4, Pages (April 2009) DOI: /jid Copyright © 2009 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Q203K mutation in the BRM gene. DHPLC chromatograph (a) of PCR-amplified BRM exon 4 from wild-type DNA, mutant DNA generated by site directed mutagenesis, and SCC DNA. The DHPLC heteroduplex traces are generated using proprietary software. The sequence variation is represented by a differently shaped peak when compared with the wild-type profile. Corresponding sequence profiles (b) for the same tumor compared with germline DNA from the same patient show the single-base substitution. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2009 The Society for Investigative Dermatology, Inc Terms and Conditions


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