1. Robust and automated crystal screening
Cassette kits and cassettes distributed to CC groups
From initial design to production
Used since June 2002 Implemented at all SSRL beamlines
Large-scale crystal shipping and storage capacity
Integration with BLU-ICE software
Automated sample mounting
Automated sample alignment
Automated diffraction images

2. Local and central management of data
Majority of data now in JCSG DB
7942 crystals screened from 222 targets
254 datasets from 121 targets
Growing reliance on the JCSG DB
High priority upload of data to JCSG DB
Active crystal report
Structure solution tracking
Local SDC “dataset” database

3. SSRL down, “X-rays On” at 9-2!!
Increased screening capacity during SSRL shutdown
X-ray MicroMax-002 generator installed June 2003
SSRL automated screening system used
2311 crystals screened in 5 months
~40 structures solved

4. “Intense” beam time schedule without SSRL
Fantastic effort from SDC team, with valuable participation from CC and SMB colleagues
5-6 days per month at ALS
2-3 days per month at APS
Refinement progress has been slower than desired…
Looking forward to much more streamlined operation under SPEAR3

5. Fine screening crystallization at SSRL
Improve diffraction quality for borderline targets
9 proteins received from GNF
67 crystals screened
5 structures solved (TM0542, TM0574, TM1464, TM1780, TM1782)
3 structures in progress with diffracting crystals (TM0559, TM1246, TM1739)
In addition several complexes of TM0449, TM0574 and TM1780 pursued by I. Mathews.