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Effect of Prophylactic Fentanyl Buccal Tablet on Episodic Exertional Dyspnea: A Pilot Double-Blind Randomized Controlled Trial  David Hui, MD, MSc, Kelly.

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Presentation on theme: "Effect of Prophylactic Fentanyl Buccal Tablet on Episodic Exertional Dyspnea: A Pilot Double-Blind Randomized Controlled Trial  David Hui, MD, MSc, Kelly."— Presentation transcript:

1 Effect of Prophylactic Fentanyl Buccal Tablet on Episodic Exertional Dyspnea: A Pilot Double-Blind Randomized Controlled Trial  David Hui, MD, MSc, Kelly Kilgore, BSc, Susan Frisbee-Hume, MS, Minjeong Park, PhD, Diane Liu, MS, Diwakar D. Balachandran, MD, Eduardo Bruera, MD  Journal of Pain and Symptom Management  Volume 54, Issue 6, Pages (December 2017) DOI: /j.jpainsymman Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

2 Fig. 1 CONSORT diagram. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

3 Fig. 2 Change in dyspnea scores with and without study medications. a) Without study medications, the two study groups had similar increase in dyspnea with exertion during Walk 1. b) With study medication, both study groups experienced a lower level of increase in dyspnea with exertion during Walk 2 compared with the first walk. Patients who received fentanyl buccal tablet had a trend toward greater level of dyspnea relief compared with placebo (estimate −0.25, P = 0.068). The error bars represent 95% CI. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

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