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The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis  Dr Laura J Shallcross, MBBS, Ellen.

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Presentation on theme: "The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis  Dr Laura J Shallcross, MBBS, Ellen."— Presentation transcript:

1 The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis  Dr Laura J Shallcross, MBBS, Ellen Fragaszy, MSc, Prof Anne M Johnson, MD, Andrew C Hayward, MD  The Lancet Infectious Diseases  Volume 13, Issue 1, Pages (January 2013) DOI: /S (12) Copyright © 2013 Elsevier Ltd Terms and Conditions

2 Figure 1 Study selection
The Lancet Infectious Diseases  , 43-54DOI: ( /S (12) ) Copyright © 2013 Elsevier Ltd Terms and Conditions

3 Figure 2 Fixed-effects meta-analysis comparing the odds of infection with Panton-Valentine leucocidin-producing strain for Staphylococcus aureus pneumonia versus skin and soft-tissue disease OR=odds ratio The Lancet Infectious Diseases  , 43-54DOI: ( /S (12) ) Copyright © 2013 Elsevier Ltd Terms and Conditions

4 Figure 3 Random-effects meta-analysis comparing the odds of infection with a Panton-Valentine leucocidin-producing strain for Staphylococcus aureus musculoskeletal disease versus skin and soft-tissue infection OR=odds ratio. The Lancet Infectious Diseases  , 43-54DOI: ( /S (12) ) Copyright © 2013 Elsevier Ltd Terms and Conditions

5 Figure 4 Fixed-effects meta-analysis comparing the odds of infection with a Panton-Valentine leucocidin-producing strain for Staphylococcus aureus bacteraemia versus skin and soft-tissue disease OR=odds ratio. The Lancet Infectious Diseases  , 43-54DOI: ( /S (12) ) Copyright © 2013 Elsevier Ltd Terms and Conditions

6 Figure 5 Fixed-effects meta-analysis comparing the odds of infection with a Panton-Valentine leucocidin-producing strain for Staphylococcus aureus abscesses or furuncles to all other presentations of S aureus disease OR=odds ratio. The Lancet Infectious Diseases  , 43-54DOI: ( /S (12) ) Copyright © 2013 Elsevier Ltd Terms and Conditions

7 Figure 6 Random-effects meta-analysis comparing the odds of colonisation with Panton-Valentine leucocidin-producing Staphylococcus aureus versus Panton-Valentine leucocidin-positive skin and soft-tissue infection OR=odds ratio. The Lancet Infectious Diseases  , 43-54DOI: ( /S (12) ) Copyright © 2013 Elsevier Ltd Terms and Conditions

8 Figure 7 Clinical iceberg of Panton-Valentine leucocidin-associated infection The Lancet Infectious Diseases  , 43-54DOI: ( /S (12) ) Copyright © 2013 Elsevier Ltd Terms and Conditions


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