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Normalization of QT interval duration in a long QT syndrome patient during pregnancy and the postpartum period due to sex hormone effects on cardiac repolarization 

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Presentation on theme: "Normalization of QT interval duration in a long QT syndrome patient during pregnancy and the postpartum period due to sex hormone effects on cardiac repolarization "— Presentation transcript:

1 Normalization of QT interval duration in a long QT syndrome patient during pregnancy and the postpartum period due to sex hormone effects on cardiac repolarization  Katja E. Odening, MD, Gideon Koren, MD, Malcolm Kirk, MD, FHRS  HeartRhythm Case Reports  Volume 2, Issue 3, Pages (May 2016) DOI: /j.hrcr Copyright © 2016 Heart Rhythm Society Terms and Conditions

2 Figure 1 A: Electrocardiogram (ECG) recording from our patient in May 2005 showing a very long heart rate–corrected QT interval (QTc) of 575 ms (QT 560 ms, RR 960 ms). B: ECG recording from the same patient in November 2006 during the postpartum period while under progesterone-releasing intrauterine device treatment, showing for the first time a normalized QTc interval of 410 ms (QT 360 ms, RR 750 ms). C: ECG recording from our patient during pregnancy in December 2007, still showing a normalized QTc of 410 ms (QT 350 ms, RR 720 ms). D: ECG recording from the same patient after stopping breastfeeding in August 2011 showing—for the first time since 2005—again a QTc interval duration within her initial range of 497 ms (QT 500 ms, RR 990 ms). All traces were acquired at a speed of 25 mm/s. HeartRhythm Case Reports 2016 2, DOI: ( /j.hrcr ) Copyright © 2016 Heart Rhythm Society Terms and Conditions

3 Figure 2 Illustration of progesterone (Prog; blue, pg/mL) and estradiol (EST; red, ng/mL) levels and Prog/EST ratios in women during menstrual cycle, pregnancy, and postpartum phase. Indicated are heart rate–corrected QT interval (QTc) durations in our patient at baseline, during pregnancy, and during postpartum while breastfeeding. Hormone levels from references.8,13–15 HeartRhythm Case Reports 2016 2, DOI: ( /j.hrcr ) Copyright © 2016 Heart Rhythm Society Terms and Conditions

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