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Volume 137, Issue 3, Pages e3 (September 2009)

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Presentation on theme: "Volume 137, Issue 3, Pages e3 (September 2009)"— Presentation transcript:

1 Volume 137, Issue 3, Pages 834-840.e3 (September 2009)
Analysis of HLA and Non-HLA Alleles Can Identify Individuals at High Risk for Celiac Disease  Jihane Romanos, Cleo C. van Diemen, Ilja M. Nolte, Gosia Trynka, Alexandra Zhernakova, Jingyuan Fu, Maria Teresa Bardella, Donatella Barisani, Ross McManus, David A. van Heel, Cisca Wijmenga  Gastroenterology  Volume 137, Issue 3, Pages e3 (September 2009) DOI: /j.gastro Copyright © 2009 AGA Institute Terms and Conditions

2 Figure 1 Frequency distribution of HLA (A) and non-HLA loci (B) in cases and controls. Gastroenterology  , e3DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

3 Figure 2 Risk and frequency distribution of non-HLA loci in DQ2 positive individuals. Gastroenterology  , e3DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

4 Figure 3 Reclassification of individuals at intermediate risk to high risk for CD in the initial (A) and the validation cohort (B). Gastroenterology  , e3DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

5 Supplemental Figure 1 Increase risk of CD with increase number of non-HLA risk alleles, with the reference group being ≤5. Gastroenterology  , e3DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

6 Supplemental Figure 2 Simulation of additional risk alleles to the genetic risk model. Gastroenterology  , e3DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions


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