1. SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain† 
Y. Niiyama, T. Kawamata, J. Yamamoto, S. Furuse, A. Namiki 
British Journal of Anaesthesia 
Volume 102, Issue 2, Pages (February 2009)
DOI: /bja/aen347
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
Effects of intraperitoneal morphine on bone cancer pain-related behaviours. All behaviours were analysed at day 14 after sarcoma injection. (a) The limb use score during spontaneous ambulation; (b) the weight-bearing score during spontaneous standing; and (c) the number of spontaneous flinches during a 2 min observation period. Values in (a) and (b) were represented as medians with first and third quartiles, and 10th and 90th percentiles. Values in (c) were represented as mean (sd). *P<0.05 vs pre. n=10–11 in each treatment group. ‘Pre’ indicates ‘before the drug administration’.
British Journal of Anaesthesia  , DOI: ( /bja/aen347)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
Effects of intraperitoneal SB on bone cancer pain-related behaviours. All behaviours were analysed at day 14 after sarcoma injection. (a) The limb use score during spontaneous ambulation; (b) the weight-bearing score during spontaneous standing; and (c) the number of spontaneous flinches during a 2 min observation period. Values in (a) and (b) were represented as medians with first and third quartiles, and 10th and 90th percentiles. Values in (c) were represented as mean (sd). *P<0.05 vs pre. n=10–11 in each treatment group. ‘Pre’ indicates ‘before the drug administration’.
British Journal of Anaesthesia  , DOI: ( /bja/aen347)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
Effects of the combination of morphine and SB on bone cancer pain-related behaviours. All behaviours were analysed at day 14 after sarcoma injection. (a) The limb use score during spontaneous ambulation; (b) the weight-bearing score during spontaneous standing; and (c) the number of spontaneous flinches during a 2 min observation period. Values in (a) and (b) were represented as medians with first and third quartiles, and 10th and 90th percentiles. Values in (c) were represented as mean (sd). *P<0.05 vs pre. n=10–11 in each treatment group. ‘Pre’ indicates ‘before the drug administration’.
British Journal of Anaesthesia  , DOI: ( /bja/aen347)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

5. Fig 4
AUC of morphine alone and the combination of morphine and SB on bone cancer pain-related behaviours. All behaviours were analysed at day 14 after sarcoma injection. (a) The limb use score during spontaneous ambulation; (b) the weight-bearing score during spontaneous standing; and (c) the number of spontaneous flinches during a 2 min observation period. AUC was expressed as means (sd). *P<0.05 vs morphine alone. n=10–11 in each treatment group. NS, not significant. – and + indicate ‘in the absence of SB mg kg−1' and ‘in the presence of SB mg kg−1', respectively.
British Journal of Anaesthesia  , DOI: ( /bja/aen347)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions