1. Molecular and morphological analysis of Pitrm1+/− mouse brain
Molecular and morphological analysis of Pitrm1+/− mouse brain Western blot analysis of amyloid precursor protein (APP) in 6‐mo male mice. GAPDH was used as a loading control. Densitometric analysis on a total of five independent samples is shown in the histogram on the right. ***P =   Data are presented as mean ± SD. Statistical analysis was performed using unpaired, two‐tailed Student's t‐test.Morphological analysis of an AD subject and of Pitrm1+/− and Pitrm1+/+ mouse brains. TF: thioflavin T (thalamus); CR: Congo red (brain cortex); PL: polarised light (same sections as those stained with CR); Aβ1–42 immunostaining (pons); Ub: ubiquitin immunohistochemistry shown as brownish staining (brain cortex). Scale bar indicates 20 μm. Source data are available online for this figure.
Dario Brunetti et al. EMBO Mol Med. 2016;8:
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