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Comparative Efficacy of Ceritinib and Crizotinib as Initial ALK–Targeted Therapies in Previously Treated Advanced NSCLC: An Adjusted Comparison with External.

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Presentation on theme: "Comparative Efficacy of Ceritinib and Crizotinib as Initial ALK–Targeted Therapies in Previously Treated Advanced NSCLC: An Adjusted Comparison with External."— Presentation transcript:

1 Comparative Efficacy of Ceritinib and Crizotinib as Initial ALK–Targeted Therapies in Previously Treated Advanced NSCLC: An Adjusted Comparison with External Controls  Daniel Shao-Weng Tan, BSc, M.B.B.S., MRCP, António Araújo, MD, PhD, Jie Zhang, PhD, James Signorovitch, PhD, Zheng-Yi Zhou, PhD, Xiaopeng Cai, MSc, Geoffrey Liu, MD, FRCPC  Journal of Thoracic Oncology  Volume 11, Issue 9, Pages (September 2016) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Patient selection of pooled ceritinib- and crizotinib-treated populations. Individual patient data for ceritinib-treated patients were pooled from two single-arm trials (ASCEND-1 and ASCEND-3). Summary baseline characteristics and efficacy outcomes for crizotinib-treated patients were extracted from three published studies (PROFILE 1001, PROFILE 1005, and PROFILE 1007). Previously treated patients without prior exposure to anaplastic lymphoma receptor tyrosine kinase gene (ALK)-targeted therapies were selected as the primary analysis sample. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Overall survival (OS) and progression-free survival (PFS) between balanced ceritinib- and crizotinib-treated populations. (A) Kaplan-Meier estimates of OS after matching adjustment. The median OS was not reached with ceritinib as compared with 20.5 months with crizotinib. (B) Kaplan-Meier estimates of PFS after matching adjustment. The median PFS was 13.8 months with ceritinib as compared with 8.3 months with crizotinib. CI, confidence interval. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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