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Intra-articular supplementation with recombinant human GDF5 arrests disease progression and stimulates cartilage regeneration in the rat medial meniscus.

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Presentation on theme: "Intra-articular supplementation with recombinant human GDF5 arrests disease progression and stimulates cartilage regeneration in the rat medial meniscus."— Presentation transcript:

1 Intra-articular supplementation with recombinant human GDF5 arrests disease progression and stimulates cartilage regeneration in the rat medial meniscus transection (MMT) model of osteoarthritis  B.A. Byers, W.R. Parrish, J. Geesin, U. Herzberg, S. Wadsworth, A.M. Bendele, B.J. Story  Osteoarthritis and Cartilage  Volume 22, Pages S471-S472 (April 2014) DOI: /j.joca Copyright © Terms and Conditions

2 Figure 1) Representative micrographs of the medial tibial plateau (bottom) and medial femoral condyle (top) from study # 3. 50X original magnification Osteoarthritis and Cartilage  , S471-S472DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Figure 2) Quantitation of the effects of rhGDF5 intra-articular therapy on significant cartilage lesion width of the medial tibial plateau. Day 21 untreated group indicates the extent of cartilage erosion present at the onset of therapy. Data represent 15 rats/group from study # 3. Osteoarthritis and Cartilage  , S471-S472DOI: ( /j.joca ) Copyright © Terms and Conditions


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